Innovative Extraction Techniques Using Deep Eutectic Solvents and Analytical Methods for the Isolation and Characterization of Natural Bioactive Compounds from Plant Material

The growing interest of the food, pharmaceutical and cosmetics industries in naturally occurring bioactive compounds or secondary plant metabolites also leads to a growing demand for the development of new and more effective analysis and isolation techniques. The extraction of bioactive compounds fr...

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Main Authors: Milena Ivanović, Maša Islamčević Razboršek, Mitja Kolar
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Plants
Subjects:
Online Access:https://www.mdpi.com/2223-7747/9/11/1428
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author Milena Ivanović
Maša Islamčević Razboršek
Mitja Kolar
author_facet Milena Ivanović
Maša Islamčević Razboršek
Mitja Kolar
author_sort Milena Ivanović
collection DOAJ
description The growing interest of the food, pharmaceutical and cosmetics industries in naturally occurring bioactive compounds or secondary plant metabolites also leads to a growing demand for the development of new and more effective analysis and isolation techniques. The extraction of bioactive compounds from plant material has always been a challenge, accompanied by increasingly strict control requirements for the final products and a growing interest in environmental protection. However, great efforts have been made in this direction and today a considerable number of innovative extraction techniques have been developed using green, environmentally friendly solvents. These solvents include the deep eutectic solvents (DES) and their natural equivalents, the natural deep eutectic solvents (NADES). Due to their adjustable physical-chemical properties and their green character, it is expected that DES/NADES could be the most widely used solvents in the future, not only in extraction processes but also in other research areas such as catalysis, electrochemistry or organic synthesis. Consequently, this review provided an up-to-date systematic overview of the use of DES/NADES in combination with innovative extraction techniques for the isolation of bioactive compounds from various plant materials. The topicality of the field was confirmed by a detailed search on the platform WoS (Web of Science), which resulted in more than 100 original research papers on DES/NADES for bioactive compounds in the last three years. Besides the isolation of bioactive compounds from plants, different analytical methods are presented and discussed.
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spelling doaj.art-15716de6137a4717b535605145c9a4102023-11-20T18:22:50ZengMDPI AGPlants2223-77472020-10-01911142810.3390/plants9111428Innovative Extraction Techniques Using Deep Eutectic Solvents and Analytical Methods for the Isolation and Characterization of Natural Bioactive Compounds from Plant MaterialMilena Ivanović0Maša Islamčević Razboršek1Mitja Kolar2Faculty of Chemistry and Chemical Engineering, University of Maribor, Smetanova ulica 17, SI-2000 Maribor, SloveniaFaculty of Chemistry and Chemical Engineering, University of Maribor, Smetanova ulica 17, SI-2000 Maribor, SloveniaFaculty of Chemistry and Chemical Technology, University of Ljubljana, Večna Pot 113, SI-1000 Ljubljana, SloveniaThe growing interest of the food, pharmaceutical and cosmetics industries in naturally occurring bioactive compounds or secondary plant metabolites also leads to a growing demand for the development of new and more effective analysis and isolation techniques. The extraction of bioactive compounds from plant material has always been a challenge, accompanied by increasingly strict control requirements for the final products and a growing interest in environmental protection. However, great efforts have been made in this direction and today a considerable number of innovative extraction techniques have been developed using green, environmentally friendly solvents. These solvents include the deep eutectic solvents (DES) and their natural equivalents, the natural deep eutectic solvents (NADES). Due to their adjustable physical-chemical properties and their green character, it is expected that DES/NADES could be the most widely used solvents in the future, not only in extraction processes but also in other research areas such as catalysis, electrochemistry or organic synthesis. Consequently, this review provided an up-to-date systematic overview of the use of DES/NADES in combination with innovative extraction techniques for the isolation of bioactive compounds from various plant materials. The topicality of the field was confirmed by a detailed search on the platform WoS (Web of Science), which resulted in more than 100 original research papers on DES/NADES for bioactive compounds in the last three years. Besides the isolation of bioactive compounds from plants, different analytical methods are presented and discussed.https://www.mdpi.com/2223-7747/9/11/1428bioactive compoundsplant materialanalytical methodsdeep eutectic solvents (DES)natural deep eutectic solvents (NADES)innovative extraction techniques
spellingShingle Milena Ivanović
Maša Islamčević Razboršek
Mitja Kolar
Innovative Extraction Techniques Using Deep Eutectic Solvents and Analytical Methods for the Isolation and Characterization of Natural Bioactive Compounds from Plant Material
Plants
bioactive compounds
plant material
analytical methods
deep eutectic solvents (DES)
natural deep eutectic solvents (NADES)
innovative extraction techniques
title Innovative Extraction Techniques Using Deep Eutectic Solvents and Analytical Methods for the Isolation and Characterization of Natural Bioactive Compounds from Plant Material
title_full Innovative Extraction Techniques Using Deep Eutectic Solvents and Analytical Methods for the Isolation and Characterization of Natural Bioactive Compounds from Plant Material
title_fullStr Innovative Extraction Techniques Using Deep Eutectic Solvents and Analytical Methods for the Isolation and Characterization of Natural Bioactive Compounds from Plant Material
title_full_unstemmed Innovative Extraction Techniques Using Deep Eutectic Solvents and Analytical Methods for the Isolation and Characterization of Natural Bioactive Compounds from Plant Material
title_short Innovative Extraction Techniques Using Deep Eutectic Solvents and Analytical Methods for the Isolation and Characterization of Natural Bioactive Compounds from Plant Material
title_sort innovative extraction techniques using deep eutectic solvents and analytical methods for the isolation and characterization of natural bioactive compounds from plant material
topic bioactive compounds
plant material
analytical methods
deep eutectic solvents (DES)
natural deep eutectic solvents (NADES)
innovative extraction techniques
url https://www.mdpi.com/2223-7747/9/11/1428
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AT masaislamcevicrazborsek innovativeextractiontechniquesusingdeepeutecticsolventsandanalyticalmethodsfortheisolationandcharacterizationofnaturalbioactivecompoundsfromplantmaterial
AT mitjakolar innovativeextractiontechniquesusingdeepeutecticsolventsandanalyticalmethodsfortheisolationandcharacterizationofnaturalbioactivecompoundsfromplantmaterial