Serum Sphingosine 1-Phosphate (S1P): A Novel Diagnostic Biomarker in Early Acute Ischemic Stroke
Background: Sphingosine 1-phosphate (S1P) is a lipid metabolite that mediates various physiological processes, including vascular endothelial cell function, inflammation, coagulation/thrombosis, and angiogenesis. As a result, S1P may contribute to the pathogenesis of stroke.Objective: This study aim...
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2020.00985/full |
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| author | Jia Liu Jia Liu Jia Liu Kazuo Sugimoto Kazuo Sugimoto Yuanbo Cao Yuanbo Cao Masahiro Mori Li Guo Li Guo Guojun Tan Guojun Tan |
| author_facet | Jia Liu Jia Liu Jia Liu Kazuo Sugimoto Kazuo Sugimoto Yuanbo Cao Yuanbo Cao Masahiro Mori Li Guo Li Guo Guojun Tan Guojun Tan |
| author_sort | Jia Liu |
| collection | DOAJ |
| description | Background: Sphingosine 1-phosphate (S1P) is a lipid metabolite that mediates various physiological processes, including vascular endothelial cell function, inflammation, coagulation/thrombosis, and angiogenesis. As a result, S1P may contribute to the pathogenesis of stroke.Objective: This study aimed to evaluate the diagnostic value of serum S1P in acute stroke.Method: A total of 72 patients with ischemic stroke, 36 patients with hemorrhagic stroke, and 65 controls were enrolled. Serum S1P was detected by enzyme-linked immunosorbent assay (ELISA).Results: Receiver operating characteristic curve analysis demonstrated that serum S1P could discriminate ischemic stroke from hemorrhagic stroke in both total population and subgroup analyses of samples obtained within 24 h of symptom onset (subgroup < 24h) (area under curve, AUCTotal = 0.64, P = 0.017; AUCSubgroup < 24h = 0.91, P < 0.001) and controls (AUCTotal = 0.62, P = 0.013; AUCSubgroup <24h = 0.83, P < 0.001). Furthermore, S1P showed higher efficacy than high-density lipoprotein cholesterol (HDL-C) in discriminating ischemic stroke from controls in the total population (PS1P = 0.013, PHDL−C = 0.366) and in the subgroup analysis (i.e., <24 h; PS1P < 0.001, PHDL−C = 0.081). Additionally, lower serum S1P was associated with cervical artery plaques (P = 0.021) in controls and with dyslipidemia (P = 0.036) and milder neurological impairment evaluated by the National Institute of Health Stroke Scale (NIHSS, P = 0.047) in the ischemic stroke group.Conclusions: The present study preliminarily investigated the diagnostic value of serum S1P in acute stroke. Decreased serum S1P may become a potential biomarker for early acute ischemic stroke and can indicate disease severity. |
| first_indexed | 2024-12-14T10:01:55Z |
| format | Article |
| id | doaj.art-1572cdf1cfb2459cbf34a9ff5569f18d |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-14T10:01:55Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj.art-1572cdf1cfb2459cbf34a9ff5569f18d2022-12-21T23:07:14ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-09-011110.3389/fneur.2020.00985560395Serum Sphingosine 1-Phosphate (S1P): A Novel Diagnostic Biomarker in Early Acute Ischemic StrokeJia Liu0Jia Liu1Jia Liu2Kazuo Sugimoto3Kazuo Sugimoto4Yuanbo Cao5Yuanbo Cao6Masahiro Mori7Li Guo8Li Guo9Guojun Tan10Guojun Tan11Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, ChinaNeurological Laboratory of Hebei Province, Shijiazhuang, ChinaDepartment of Neurology, Graduate School of Medicine, Chiba University, Chiba, JapanDepartment of Neurology, Dongzhimen Affiliated Hospital, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Neurology, Graduate School of Medicine, Chiba University, Chiba, JapanDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, ChinaNeurological Laboratory of Hebei Province, Shijiazhuang, ChinaDepartment of Neurology, Graduate School of Medicine, Chiba University, Chiba, JapanDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, ChinaNeurological Laboratory of Hebei Province, Shijiazhuang, ChinaDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, ChinaNeurological Laboratory of Hebei Province, Shijiazhuang, ChinaBackground: Sphingosine 1-phosphate (S1P) is a lipid metabolite that mediates various physiological processes, including vascular endothelial cell function, inflammation, coagulation/thrombosis, and angiogenesis. As a result, S1P may contribute to the pathogenesis of stroke.Objective: This study aimed to evaluate the diagnostic value of serum S1P in acute stroke.Method: A total of 72 patients with ischemic stroke, 36 patients with hemorrhagic stroke, and 65 controls were enrolled. Serum S1P was detected by enzyme-linked immunosorbent assay (ELISA).Results: Receiver operating characteristic curve analysis demonstrated that serum S1P could discriminate ischemic stroke from hemorrhagic stroke in both total population and subgroup analyses of samples obtained within 24 h of symptom onset (subgroup < 24h) (area under curve, AUCTotal = 0.64, P = 0.017; AUCSubgroup < 24h = 0.91, P < 0.001) and controls (AUCTotal = 0.62, P = 0.013; AUCSubgroup <24h = 0.83, P < 0.001). Furthermore, S1P showed higher efficacy than high-density lipoprotein cholesterol (HDL-C) in discriminating ischemic stroke from controls in the total population (PS1P = 0.013, PHDL−C = 0.366) and in the subgroup analysis (i.e., <24 h; PS1P < 0.001, PHDL−C = 0.081). Additionally, lower serum S1P was associated with cervical artery plaques (P = 0.021) in controls and with dyslipidemia (P = 0.036) and milder neurological impairment evaluated by the National Institute of Health Stroke Scale (NIHSS, P = 0.047) in the ischemic stroke group.Conclusions: The present study preliminarily investigated the diagnostic value of serum S1P in acute stroke. Decreased serum S1P may become a potential biomarker for early acute ischemic stroke and can indicate disease severity.https://www.frontiersin.org/article/10.3389/fneur.2020.00985/fullstrokeischemic strokehemorrhagic strokesphingosine 1-phosphate (S1P)high-density lipoprotein cholesterol (HDL-C)biomarker |
| spellingShingle | Jia Liu Jia Liu Jia Liu Kazuo Sugimoto Kazuo Sugimoto Yuanbo Cao Yuanbo Cao Masahiro Mori Li Guo Li Guo Guojun Tan Guojun Tan Serum Sphingosine 1-Phosphate (S1P): A Novel Diagnostic Biomarker in Early Acute Ischemic Stroke Frontiers in Neurology stroke ischemic stroke hemorrhagic stroke sphingosine 1-phosphate (S1P) high-density lipoprotein cholesterol (HDL-C) biomarker |
| title | Serum Sphingosine 1-Phosphate (S1P): A Novel Diagnostic Biomarker in Early Acute Ischemic Stroke |
| title_full | Serum Sphingosine 1-Phosphate (S1P): A Novel Diagnostic Biomarker in Early Acute Ischemic Stroke |
| title_fullStr | Serum Sphingosine 1-Phosphate (S1P): A Novel Diagnostic Biomarker in Early Acute Ischemic Stroke |
| title_full_unstemmed | Serum Sphingosine 1-Phosphate (S1P): A Novel Diagnostic Biomarker in Early Acute Ischemic Stroke |
| title_short | Serum Sphingosine 1-Phosphate (S1P): A Novel Diagnostic Biomarker in Early Acute Ischemic Stroke |
| title_sort | serum sphingosine 1 phosphate s1p a novel diagnostic biomarker in early acute ischemic stroke |
| topic | stroke ischemic stroke hemorrhagic stroke sphingosine 1-phosphate (S1P) high-density lipoprotein cholesterol (HDL-C) biomarker |
| url | https://www.frontiersin.org/article/10.3389/fneur.2020.00985/full |
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