The Relationship of Energy Malnutrition, Skeletal Muscle and Physical Functional Performance in Patients with Stable Chronic Obstructive Pulmonary Disease
Weight loss is a factor that affects prognosis in patients with chronic obstructive pulmonary disease (COPD) independent of lung function. One of the major factors for weight loss is energy malnutrition. There have been no reports on the factors related to energy malnutrition in COPD patients. This...
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MDPI AG
2022-06-01
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| Online Access: | https://www.mdpi.com/2072-6643/14/13/2596 |
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| author | Manabu Tomita Masaru Uchida Yujiro Imaizumi Megumi Monji Emiko Tokushima Michihiro Kawashima |
| author_facet | Manabu Tomita Masaru Uchida Yujiro Imaizumi Megumi Monji Emiko Tokushima Michihiro Kawashima |
| author_sort | Manabu Tomita |
| collection | DOAJ |
| description | Weight loss is a factor that affects prognosis in patients with chronic obstructive pulmonary disease (COPD) independent of lung function. One of the major factors for weight loss is energy malnutrition. There have been no reports on the factors related to energy malnutrition in COPD patients. This retrospective observational study aimed to investigate these factors. We included 163 male subjects with COPD. Respiratory quotient (RQ), an index of energy malnutrition, was calculated by expiratory gas analysis using an indirect calorimeter. RQ < 0.85 was defined as the energy-malnutrition group and RQ ≥ 0.85 as the no energy-malnutrition group. Factors related to energy malnutrition were examined by multivariate and decision-tree analysis. We finally analyzed data from 56 selected subjects (median age: 74 years, BMI: 22.5 kg/m<sup>2</sup>)<b>.</b> Energy malnutrition was observed in 43%. The independent factors associated with energy malnutrition were tidal volume (VT) (OR 0.99; 95% CI 0.985–0.998; <i>p</i> = 0.015) and Th12 erector spinae muscle cross-sectional area SMI (Th12ESM<sub>SMI</sub>) (OR 0.71; 95% CI 0.535–0.946; <i>p</i> = 0.019). In decision-tree profiling of energy malnutrition, VT was extracted as the first distinguishable factor, and Th12ESM<sub>SMI</sub> as the second. In ROC analysis, VT < 647 mL (AUC, 0.72) or Th12ESM<sub>SMI</sub> < 10.1 (AUC, 0.70) was the cutoff value for energy malnutrition. Energy malnutrition may be an early warning sign of nutritional disorders. |
| first_indexed | 2024-03-09T03:59:10Z |
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| language | English |
| last_indexed | 2024-03-09T03:59:10Z |
| publishDate | 2022-06-01 |
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| series | Nutrients |
| spelling | doaj.art-1572e1462f26426fa4b9d22494eaaee22023-12-03T14:15:53ZengMDPI AGNutrients2072-66432022-06-011413259610.3390/nu14132596The Relationship of Energy Malnutrition, Skeletal Muscle and Physical Functional Performance in Patients with Stable Chronic Obstructive Pulmonary DiseaseManabu Tomita0Masaru Uchida1Yujiro Imaizumi2Megumi Monji3Emiko Tokushima4Michihiro Kawashima5Graduate School of Medicine, Kurume University, Kurume 830-0011, JapanDepartment of Respiratory Medicine, Japan Community Health Care Organization Saga Central Hospital, Saga 849-8522, JapanDepartment of Rehabilitation, Japan Community Health Care Organization Saga Central Hospital, Saga 849-8522, JapanDepartment of Respiratory Medicine, Japan Community Health Care Organization Saga Central Hospital, Saga 849-8522, JapanDepartment of Respiratory Medicine, Japan Community Health Care Organization Saga Central Hospital, Saga 849-8522, JapanDepartment of Respiratory Medicine, Japan Community Health Care Organization Saga Central Hospital, Saga 849-8522, JapanWeight loss is a factor that affects prognosis in patients with chronic obstructive pulmonary disease (COPD) independent of lung function. One of the major factors for weight loss is energy malnutrition. There have been no reports on the factors related to energy malnutrition in COPD patients. This retrospective observational study aimed to investigate these factors. We included 163 male subjects with COPD. Respiratory quotient (RQ), an index of energy malnutrition, was calculated by expiratory gas analysis using an indirect calorimeter. RQ < 0.85 was defined as the energy-malnutrition group and RQ ≥ 0.85 as the no energy-malnutrition group. Factors related to energy malnutrition were examined by multivariate and decision-tree analysis. We finally analyzed data from 56 selected subjects (median age: 74 years, BMI: 22.5 kg/m<sup>2</sup>)<b>.</b> Energy malnutrition was observed in 43%. The independent factors associated with energy malnutrition were tidal volume (VT) (OR 0.99; 95% CI 0.985–0.998; <i>p</i> = 0.015) and Th12 erector spinae muscle cross-sectional area SMI (Th12ESM<sub>SMI</sub>) (OR 0.71; 95% CI 0.535–0.946; <i>p</i> = 0.019). In decision-tree profiling of energy malnutrition, VT was extracted as the first distinguishable factor, and Th12ESM<sub>SMI</sub> as the second. In ROC analysis, VT < 647 mL (AUC, 0.72) or Th12ESM<sub>SMI</sub> < 10.1 (AUC, 0.70) was the cutoff value for energy malnutrition. Energy malnutrition may be an early warning sign of nutritional disorders.https://www.mdpi.com/2072-6643/14/13/2596chronic obstructive pulmonary diseaseenergy malnutritionerector spinae muscleindirect calorimetryphysical functional performancerespiratory quotient |
| spellingShingle | Manabu Tomita Masaru Uchida Yujiro Imaizumi Megumi Monji Emiko Tokushima Michihiro Kawashima The Relationship of Energy Malnutrition, Skeletal Muscle and Physical Functional Performance in Patients with Stable Chronic Obstructive Pulmonary Disease Nutrients chronic obstructive pulmonary disease energy malnutrition erector spinae muscle indirect calorimetry physical functional performance respiratory quotient |
| title | The Relationship of Energy Malnutrition, Skeletal Muscle and Physical Functional Performance in Patients with Stable Chronic Obstructive Pulmonary Disease |
| title_full | The Relationship of Energy Malnutrition, Skeletal Muscle and Physical Functional Performance in Patients with Stable Chronic Obstructive Pulmonary Disease |
| title_fullStr | The Relationship of Energy Malnutrition, Skeletal Muscle and Physical Functional Performance in Patients with Stable Chronic Obstructive Pulmonary Disease |
| title_full_unstemmed | The Relationship of Energy Malnutrition, Skeletal Muscle and Physical Functional Performance in Patients with Stable Chronic Obstructive Pulmonary Disease |
| title_short | The Relationship of Energy Malnutrition, Skeletal Muscle and Physical Functional Performance in Patients with Stable Chronic Obstructive Pulmonary Disease |
| title_sort | relationship of energy malnutrition skeletal muscle and physical functional performance in patients with stable chronic obstructive pulmonary disease |
| topic | chronic obstructive pulmonary disease energy malnutrition erector spinae muscle indirect calorimetry physical functional performance respiratory quotient |
| url | https://www.mdpi.com/2072-6643/14/13/2596 |
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