| Summary: | The aim of this study is to assess the relative risk of cerebral venous sinus thrombosis (CVST) in Oral contraceptive pills (OCP) users compared with a control group of non-hormone users. Patients & methods: This retrospective case-control, age – group matched study done in about two years and included 40 female patients and 30 control females, aged 30–50 years-with 50% of them above the age of 35 years. All patients diagnosed as CVST with the consumption of OCP were included in the study. The diagnosis is based on the MRI & MRV study. T1, T2, FLAIR &Diffusion weighted image. The MRV was done using the 2 D-TOF technique. Results: The MRI result was negative (no parenchymal changes) in 16 patients (40%), and positive in the remaining 60%; 12 patients (30%) showed haemorrhagic infarction only, represented by heterogeneous mixed hypo and hyperintesity in the brain parenchyma with brain edema and 8 patients (20%) showed non-haemorrhagic infarction in the form of low SI in T1WI and a high SI in T2WI and FLAIR and restricted diffusion on DWI, 4 (10%) patients showed a parasagittal high T2 SI indicating superior sagittal sinus thrombosis. The control group showed no parenchymal changes in four (20%) females, but showed hemorrhagic infarction in eight (40%) females, and non-hemorrhagic infarction in six (30%) females and parasagittal high T2 SI in two (10%) females. Conclusion: The risk of CVST increased more in women taking OCP than in non-hormonal users. To reduce the risk, Knowledge of it is of crucial importance. Keywords: MRI, MRV, Cerebral venous sinus, Contraceptive pills
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