Epigenetic Regulation of Circadian Rhythm and Its Possible Role in Diabetes Mellitus
This review aims to summarize the knowledge about the relationship between circadian rhythms and their influence on the development of type 2 diabetes mellitus (T2DM) and metabolic syndrome. Circadian rhythms are controlled by internal molecular feedback loops that synchronize the organism with the...
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MDPI AG
2020-04-01
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author | Michael Hudec Pavlina Dankova Roman Solc Nardjas Bettazova Marie Cerna |
author_facet | Michael Hudec Pavlina Dankova Roman Solc Nardjas Bettazova Marie Cerna |
author_sort | Michael Hudec |
collection | DOAJ |
description | This review aims to summarize the knowledge about the relationship between circadian rhythms and their influence on the development of type 2 diabetes mellitus (T2DM) and metabolic syndrome. Circadian rhythms are controlled by internal molecular feedback loops that synchronize the organism with the external environment. These loops are affected by genetic and epigenetic factors. Genetic factors include polymorphisms and mutations of circadian genes. The expression of circadian genes is regulated by epigenetic mechanisms that change from prenatal development to old age. Epigenetic modifications are influenced by the external environment. Most of these modifications are affected by our own life style. Irregular circadian rhythm and low quality of sleep have been shown to increase the risk of developing T2DM and other metabolic disorders. Here, we attempt to provide a wide description of mutual relationships between epigenetic regulation, circadian rhythm, aging process and highlight new evidences that show possible therapeutic advance in the field of chrono-medicine which will be more important in the upcoming years. |
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issn | 1661-6596 1422-0067 |
language | English |
last_indexed | 2024-03-10T20:16:05Z |
publishDate | 2020-04-01 |
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series | International Journal of Molecular Sciences |
spelling | doaj.art-1573ad5e6ace4562b021257c6b8baa302023-11-19T22:33:55ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-04-01218300510.3390/ijms21083005Epigenetic Regulation of Circadian Rhythm and Its Possible Role in Diabetes MellitusMichael Hudec0Pavlina Dankova1Roman Solc2Nardjas Bettazova3Marie Cerna4Department of Medical Genetics, Third Faculty of Medicine, Charles University; Ruská 87, 100 00 Prague, Czech RepublicDepartment of Anthropology and Human Genetics, Faculty of Science, Charles University; Viničná 7, 128 00 Prague, Czech RepublicDepartment of Anthropology and Human Genetics, Faculty of Science, Charles University; Viničná 7, 128 00 Prague, Czech RepublicDepartment of Medical Genetics, Third Faculty of Medicine, Charles University; Ruská 87, 100 00 Prague, Czech RepublicDepartment of Medical Genetics, Third Faculty of Medicine, Charles University; Ruská 87, 100 00 Prague, Czech RepublicThis review aims to summarize the knowledge about the relationship between circadian rhythms and their influence on the development of type 2 diabetes mellitus (T2DM) and metabolic syndrome. Circadian rhythms are controlled by internal molecular feedback loops that synchronize the organism with the external environment. These loops are affected by genetic and epigenetic factors. Genetic factors include polymorphisms and mutations of circadian genes. The expression of circadian genes is regulated by epigenetic mechanisms that change from prenatal development to old age. Epigenetic modifications are influenced by the external environment. Most of these modifications are affected by our own life style. Irregular circadian rhythm and low quality of sleep have been shown to increase the risk of developing T2DM and other metabolic disorders. Here, we attempt to provide a wide description of mutual relationships between epigenetic regulation, circadian rhythm, aging process and highlight new evidences that show possible therapeutic advance in the field of chrono-medicine which will be more important in the upcoming years.https://www.mdpi.com/1422-0067/21/8/3005type 2 diabetes mellituscircadian clockepigenetic regulationmetabolic syndromesleepaging |
spellingShingle | Michael Hudec Pavlina Dankova Roman Solc Nardjas Bettazova Marie Cerna Epigenetic Regulation of Circadian Rhythm and Its Possible Role in Diabetes Mellitus International Journal of Molecular Sciences type 2 diabetes mellitus circadian clock epigenetic regulation metabolic syndrome sleep aging |
title | Epigenetic Regulation of Circadian Rhythm and Its Possible Role in Diabetes Mellitus |
title_full | Epigenetic Regulation of Circadian Rhythm and Its Possible Role in Diabetes Mellitus |
title_fullStr | Epigenetic Regulation of Circadian Rhythm and Its Possible Role in Diabetes Mellitus |
title_full_unstemmed | Epigenetic Regulation of Circadian Rhythm and Its Possible Role in Diabetes Mellitus |
title_short | Epigenetic Regulation of Circadian Rhythm and Its Possible Role in Diabetes Mellitus |
title_sort | epigenetic regulation of circadian rhythm and its possible role in diabetes mellitus |
topic | type 2 diabetes mellitus circadian clock epigenetic regulation metabolic syndrome sleep aging |
url | https://www.mdpi.com/1422-0067/21/8/3005 |
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