Research progress on the therapeutic effects of polysaccharides on non-alcoholic fatty liver diseases
Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease and is a leading cause of cirrhosis and hepatocellular carcinoma. Due to its complex pathophysiology, there is currently no approved therapy. Polysaccharide, a kind of natural product, possesses a wide range o...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1107551/full |
| _version_ | 1827993968966631424 |
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| author | Yu-long Hu Yu-long Hu Yu-long Hu Qiaoli Ma Qiaoli Ma Qiaoli Ma Xiaoqiang Dong Xiaoqiang Dong Xiaoqiang Dong Yuanfang Kong Juntao Cai Juntao Cai Juntao Cai Jieming Li Jieming Li Jieming Li Chunhong Dong Chunhong Dong Chunhong Dong |
| author_facet | Yu-long Hu Yu-long Hu Yu-long Hu Qiaoli Ma Qiaoli Ma Qiaoli Ma Xiaoqiang Dong Xiaoqiang Dong Xiaoqiang Dong Yuanfang Kong Juntao Cai Juntao Cai Juntao Cai Jieming Li Jieming Li Jieming Li Chunhong Dong Chunhong Dong Chunhong Dong |
| author_sort | Yu-long Hu |
| collection | DOAJ |
| description | Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease and is a leading cause of cirrhosis and hepatocellular carcinoma. Due to its complex pathophysiology, there is currently no approved therapy. Polysaccharide, a kind of natural product, possesses a wide range of pharmacological activities. Numerous preclinical studies have confirmed that polysaccharides could interfere with the occurrence and development of NAFLD at multiple interrelated levels, such as improvement of glucose and lipid metabolism, antioxidation, anti-inflammation, and regulation of gut-liver axis, thus showing great potential as novel anti-NAFLD drugs. In this paper, we reviewed the polysaccharides with anti-NAFLD effect in recent years, and also systematically analyzed their possible pharmacological mechanisms. |
| first_indexed | 2024-04-10T04:33:34Z |
| format | Article |
| id | doaj.art-1573d15a20914262a1a0dc9a7d92203a |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-10T04:33:34Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-1573d15a20914262a1a0dc9a7d92203a2023-03-10T04:41:46ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-03-011010.3389/fnut.2023.11075511107551Research progress on the therapeutic effects of polysaccharides on non-alcoholic fatty liver diseasesYu-long Hu0Yu-long Hu1Yu-long Hu2Qiaoli Ma3Qiaoli Ma4Qiaoli Ma5Xiaoqiang Dong6Xiaoqiang Dong7Xiaoqiang Dong8Yuanfang Kong9Juntao Cai10Juntao Cai11Juntao Cai12Jieming Li13Jieming Li14Jieming Li15Chunhong Dong16Chunhong Dong17Chunhong Dong18Academy of Chinese Medical Science, Henan University of Chinese Medicine, Zhengzhou, ChinaHenan Polysaccharide Research Center, Zhengzhou, ChinaHenan Key Laboratory of Chinese Medicine for Polysaccharides and Drugs Research, Zhengzhou, ChinaAcademy of Chinese Medical Science, Henan University of Chinese Medicine, Zhengzhou, ChinaHenan Polysaccharide Research Center, Zhengzhou, ChinaHenan Key Laboratory of Chinese Medicine for Polysaccharides and Drugs Research, Zhengzhou, ChinaAcademy of Chinese Medical Science, Henan University of Chinese Medicine, Zhengzhou, ChinaHenan Polysaccharide Research Center, Zhengzhou, ChinaHenan Key Laboratory of Chinese Medicine for Polysaccharides and Drugs Research, Zhengzhou, ChinaCollege of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, ChinaAcademy of Chinese Medical Science, Henan University of Chinese Medicine, Zhengzhou, ChinaHenan Polysaccharide Research Center, Zhengzhou, ChinaHenan Key Laboratory of Chinese Medicine for Polysaccharides and Drugs Research, Zhengzhou, ChinaAcademy of Chinese Medical Science, Henan University of Chinese Medicine, Zhengzhou, ChinaHenan Polysaccharide Research Center, Zhengzhou, ChinaHenan Key Laboratory of Chinese Medicine for Polysaccharides and Drugs Research, Zhengzhou, ChinaAcademy of Chinese Medical Science, Henan University of Chinese Medicine, Zhengzhou, ChinaHenan Polysaccharide Research Center, Zhengzhou, ChinaHenan Key Laboratory of Chinese Medicine for Polysaccharides and Drugs Research, Zhengzhou, ChinaNon-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease and is a leading cause of cirrhosis and hepatocellular carcinoma. Due to its complex pathophysiology, there is currently no approved therapy. Polysaccharide, a kind of natural product, possesses a wide range of pharmacological activities. Numerous preclinical studies have confirmed that polysaccharides could interfere with the occurrence and development of NAFLD at multiple interrelated levels, such as improvement of glucose and lipid metabolism, antioxidation, anti-inflammation, and regulation of gut-liver axis, thus showing great potential as novel anti-NAFLD drugs. In this paper, we reviewed the polysaccharides with anti-NAFLD effect in recent years, and also systematically analyzed their possible pharmacological mechanisms.https://www.frontiersin.org/articles/10.3389/fnut.2023.1107551/fullpolysaccharidesNAFLDNASHtherapyliver diseases |
| spellingShingle | Yu-long Hu Yu-long Hu Yu-long Hu Qiaoli Ma Qiaoli Ma Qiaoli Ma Xiaoqiang Dong Xiaoqiang Dong Xiaoqiang Dong Yuanfang Kong Juntao Cai Juntao Cai Juntao Cai Jieming Li Jieming Li Jieming Li Chunhong Dong Chunhong Dong Chunhong Dong Research progress on the therapeutic effects of polysaccharides on non-alcoholic fatty liver diseases Frontiers in Nutrition polysaccharides NAFLD NASH therapy liver diseases |
| title | Research progress on the therapeutic effects of polysaccharides on non-alcoholic fatty liver diseases |
| title_full | Research progress on the therapeutic effects of polysaccharides on non-alcoholic fatty liver diseases |
| title_fullStr | Research progress on the therapeutic effects of polysaccharides on non-alcoholic fatty liver diseases |
| title_full_unstemmed | Research progress on the therapeutic effects of polysaccharides on non-alcoholic fatty liver diseases |
| title_short | Research progress on the therapeutic effects of polysaccharides on non-alcoholic fatty liver diseases |
| title_sort | research progress on the therapeutic effects of polysaccharides on non alcoholic fatty liver diseases |
| topic | polysaccharides NAFLD NASH therapy liver diseases |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1107551/full |
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