A novel decoy strategy for polymyxin resistance in Acinetobacter baumannii
Modification of the outer membrane charge by a polymyxin B (PMB)-induced PmrAB two-component system appears to be a dominant phenomenon in PMB-resistant Acinetobacter baumannii. PMB-resistant variants and many clinical isolates also appeared to produce outer membrane vesicles (OMVs). Genomic, transc...
Main Authors: | Jaeeun Park, Misung Kim, Bora Shin, Mingyeong Kang, Jihye Yang, Tae Kwon Lee, Woojun Park |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2021-06-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/66988 |
Similar Items
-
Polymyxins Bind to the Cell Surface of Unculturable Acinetobacter baumannii and Cause Unique Dependent Resistance
by: Yan Zhu, et al.
Published: (2020-08-01) -
Emergence of polymyxin B-resistant Acinetobacter baumannii in hospitals in Rio de Janeiro
by: Gabrielle L. Genteluci, et al. -
Metabolomics revealed mechanism for the synergistic effect of sulbactam, polymyxin-B and amikacin combination against Acinetobacter baumannii
by: Shixing Zhu, et al.
Published: (2023-06-01) -
Metabolomic profiling of polymyxin-B in combination with meropenem and sulbactam against multi-drug resistant Acinetobacter baumannii
by: Shixing Zhu, et al.
Published: (2022-09-01) -
PKPD Modeling of the Inoculum Effect of Acinetobacter baumannii on Polymyxin B in vivo
by: Alexia Chauzy, et al.
Published: (2022-03-01)