Physicochemical Characterization and Antimicrobial Activity of Mechanochemically and Solvent-Based Synthesized Mn(II) Complexes of Cefixime and Cefuroxime
Mechanochemical and solvent-based complexes of Mn(II) with cefixime and cefuroxime were synthesized and characterized by melting point and conductivity measurements, elemental analysis, FTIR spectral studies, and electronic spectral analysis. The Mn(II) complexes with cefixime and cefuroxime synthes...
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Iranian Chemical Science and Technologies Association
2022-08-01
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| Series: | Chemical Review and Letters |
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| Online Access: | https://www.chemrevlett.com/article_153994_78a07a598e465f6133d514f8ee64f5cb.pdf |
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| author | Aisha Makinta Mohammed Fugu Ndahi Naomi Musa Mahmud Abubakar Ahmed |
| author_facet | Aisha Makinta Mohammed Fugu Ndahi Naomi Musa Mahmud Abubakar Ahmed |
| author_sort | Aisha Makinta |
| collection | DOAJ |
| description | Mechanochemical and solvent-based complexes of Mn(II) with cefixime and cefuroxime were synthesized and characterized by melting point and conductivity measurements, elemental analysis, FTIR spectral studies, and electronic spectral analysis. The Mn(II) complexes with cefixime and cefuroxime synthesized mechanochemically were both ash colored, while Mn(II) cefixime and cefuroxime complexes synthesized through solvent-based method were milky and ash respectively. The molar conductivity values (14.9 – 16.6 Scm2mol-1) indicate non-electrolytic nature of the complexes. The FTIR revealed that the ligands were coordinated to the Mn(II) ion through the carboxylate ions (C=O). A six coordinate octahedral geometry has been proposed for the complexes. The result of the antibacterial assay of the synthesized complexes of Mn(II) with cefuroxime generally showed better activity against Staphylococcus aureus, Streptococcus pyogenes and Methicillin-resistant Staphylococcus aureus (MRSA) than the free ligand cefuroxime. Similarly, the Mn(II) complex of cefuroxime synthesized by mechanochemical method shows higher activity against the aforementioned organisms as compared to the solution-based complex which might be as a result of solvent effect. |
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| id | doaj.art-1575bc98f5904aa3a616f1a8e21cd0f8 |
| institution | Directory Open Access Journal |
| issn | 2676-7279 2645-4947 |
| language | English |
| last_indexed | 2024-03-13T05:05:30Z |
| publishDate | 2022-08-01 |
| publisher | Iranian Chemical Science and Technologies Association |
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| series | Chemical Review and Letters |
| spelling | doaj.art-1575bc98f5904aa3a616f1a8e21cd0f82023-06-16T12:45:16ZengIranian Chemical Science and Technologies AssociationChemical Review and Letters2676-72792645-49472022-08-015426126710.22034/crl.2022.330636.1157153994Physicochemical Characterization and Antimicrobial Activity of Mechanochemically and Solvent-Based Synthesized Mn(II) Complexes of Cefixime and CefuroximeAisha Makinta0Mohammed Fugu1Ndahi Naomi2Musa Mahmud3Abubakar Ahmed4Department of Chemistry, Faculty of Science, Federal University Gashua, Yobe State, NigeriaDepartment of Pure and Applied Chemistry, Faculty of Science, University of Maiduguri, Maiduguri. Borno State, NigeriaDepartment of Pure and Applied Chemistry University of MaiduguriDepartment of Science Laboratory Technology, Mai Idiris Alooma Polytechnic, Geidam, Yobe State, NigeriaDepartment of Pure and Applied Chemistry, Faculty of Science, University of Maiduguri, Borno State, Nigeria.Mechanochemical and solvent-based complexes of Mn(II) with cefixime and cefuroxime were synthesized and characterized by melting point and conductivity measurements, elemental analysis, FTIR spectral studies, and electronic spectral analysis. The Mn(II) complexes with cefixime and cefuroxime synthesized mechanochemically were both ash colored, while Mn(II) cefixime and cefuroxime complexes synthesized through solvent-based method were milky and ash respectively. The molar conductivity values (14.9 – 16.6 Scm2mol-1) indicate non-electrolytic nature of the complexes. The FTIR revealed that the ligands were coordinated to the Mn(II) ion through the carboxylate ions (C=O). A six coordinate octahedral geometry has been proposed for the complexes. The result of the antibacterial assay of the synthesized complexes of Mn(II) with cefuroxime generally showed better activity against Staphylococcus aureus, Streptococcus pyogenes and Methicillin-resistant Staphylococcus aureus (MRSA) than the free ligand cefuroxime. Similarly, the Mn(II) complex of cefuroxime synthesized by mechanochemical method shows higher activity against the aforementioned organisms as compared to the solution-based complex which might be as a result of solvent effect.https://www.chemrevlett.com/article_153994_78a07a598e465f6133d514f8ee64f5cb.pdfmechanochemicalsolvent-basedcefiximecefuroximeantimicrobial activity |
| spellingShingle | Aisha Makinta Mohammed Fugu Ndahi Naomi Musa Mahmud Abubakar Ahmed Physicochemical Characterization and Antimicrobial Activity of Mechanochemically and Solvent-Based Synthesized Mn(II) Complexes of Cefixime and Cefuroxime Chemical Review and Letters mechanochemical solvent-based cefixime cefuroxime antimicrobial activity |
| title | Physicochemical Characterization and Antimicrobial Activity of Mechanochemically and Solvent-Based Synthesized Mn(II) Complexes of Cefixime and Cefuroxime |
| title_full | Physicochemical Characterization and Antimicrobial Activity of Mechanochemically and Solvent-Based Synthesized Mn(II) Complexes of Cefixime and Cefuroxime |
| title_fullStr | Physicochemical Characterization and Antimicrobial Activity of Mechanochemically and Solvent-Based Synthesized Mn(II) Complexes of Cefixime and Cefuroxime |
| title_full_unstemmed | Physicochemical Characterization and Antimicrobial Activity of Mechanochemically and Solvent-Based Synthesized Mn(II) Complexes of Cefixime and Cefuroxime |
| title_short | Physicochemical Characterization and Antimicrobial Activity of Mechanochemically and Solvent-Based Synthesized Mn(II) Complexes of Cefixime and Cefuroxime |
| title_sort | physicochemical characterization and antimicrobial activity of mechanochemically and solvent based synthesized mn ii complexes of cefixime and cefuroxime |
| topic | mechanochemical solvent-based cefixime cefuroxime antimicrobial activity |
| url | https://www.chemrevlett.com/article_153994_78a07a598e465f6133d514f8ee64f5cb.pdf |
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