Cyclin-Dependent Kinase 5 (CDK5)-Mediated Phosphorylation of Upstream Stimulatory Factor 2 (USF2) Contributes to Carcinogenesis
The transcription factor USF2 is supposed to have an important role in tumor development. However, the regulatory mechanisms contributing to the function of USF2 are largely unknown. Cyclin-dependent kinase 5 (CDK5) seems to be of importance since high levels of CDK5 were found in different cancers...
| Main Authors: | , , , , |
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| Format: | Article |
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MDPI AG
2019-04-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/11/4/523 |
| _version_ | 1797715894210658304 |
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| author | Tabughang Franklin Chi Tina Horbach Claudia Götz Thomas Kietzmann Elitsa Y. Dimova |
| author_facet | Tabughang Franklin Chi Tina Horbach Claudia Götz Thomas Kietzmann Elitsa Y. Dimova |
| author_sort | Tabughang Franklin Chi |
| collection | DOAJ |
| description | The transcription factor USF2 is supposed to have an important role in tumor development. However, the regulatory mechanisms contributing to the function of USF2 are largely unknown. Cyclin-dependent kinase 5 (CDK5) seems to be of importance since high levels of CDK5 were found in different cancers associated with high USF2 expression. Here, we identified USF2 as a phosphorylation target of CDK5. USF2 is phosphorylated by CDK5 at two serine residues, serine 155 and serine 222. Further, phosphorylation of USF2 at these residues was shown to stabilize the protein and to regulate cellular growth and migration. Altogether, these results delineate the importance of the CDK5-USF2 interplay in cancer cells. |
| first_indexed | 2024-03-12T08:13:35Z |
| format | Article |
| id | doaj.art-1577b1a5ef524e4aa43a0ab8ff2e84eb |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T08:13:35Z |
| publishDate | 2019-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-1577b1a5ef524e4aa43a0ab8ff2e84eb2023-09-02T19:01:34ZengMDPI AGCancers2072-66942019-04-0111452310.3390/cancers11040523cancers11040523Cyclin-Dependent Kinase 5 (CDK5)-Mediated Phosphorylation of Upstream Stimulatory Factor 2 (USF2) Contributes to CarcinogenesisTabughang Franklin Chi0Tina Horbach1Claudia Götz2Thomas Kietzmann3Elitsa Y. Dimova4Faculty of Biochemistry and Molecular Medicine, University of Oulu, 90014 Oulu, FinlandFaculty of Biochemistry and Molecular Medicine, University of Oulu, 90014 Oulu, FinlandMedical Biochemistry and Molecular Biology, Saarland University, 66421 Homburg, GermanyFaculty of Biochemistry and Molecular Medicine, University of Oulu, 90014 Oulu, FinlandFaculty of Biochemistry and Molecular Medicine, University of Oulu, 90014 Oulu, FinlandThe transcription factor USF2 is supposed to have an important role in tumor development. However, the regulatory mechanisms contributing to the function of USF2 are largely unknown. Cyclin-dependent kinase 5 (CDK5) seems to be of importance since high levels of CDK5 were found in different cancers associated with high USF2 expression. Here, we identified USF2 as a phosphorylation target of CDK5. USF2 is phosphorylated by CDK5 at two serine residues, serine 155 and serine 222. Further, phosphorylation of USF2 at these residues was shown to stabilize the protein and to regulate cellular growth and migration. Altogether, these results delineate the importance of the CDK5-USF2 interplay in cancer cells.https://www.mdpi.com/2072-6694/11/4/523upstream stimulatory factor 2 (USF2)cyclin-dependent kinase-5 (CDK5)CRISPR-Cas9phosphorylationproliferationmigration |
| spellingShingle | Tabughang Franklin Chi Tina Horbach Claudia Götz Thomas Kietzmann Elitsa Y. Dimova Cyclin-Dependent Kinase 5 (CDK5)-Mediated Phosphorylation of Upstream Stimulatory Factor 2 (USF2) Contributes to Carcinogenesis Cancers upstream stimulatory factor 2 (USF2) cyclin-dependent kinase-5 (CDK5) CRISPR-Cas9 phosphorylation proliferation migration |
| title | Cyclin-Dependent Kinase 5 (CDK5)-Mediated Phosphorylation of Upstream Stimulatory Factor 2 (USF2) Contributes to Carcinogenesis |
| title_full | Cyclin-Dependent Kinase 5 (CDK5)-Mediated Phosphorylation of Upstream Stimulatory Factor 2 (USF2) Contributes to Carcinogenesis |
| title_fullStr | Cyclin-Dependent Kinase 5 (CDK5)-Mediated Phosphorylation of Upstream Stimulatory Factor 2 (USF2) Contributes to Carcinogenesis |
| title_full_unstemmed | Cyclin-Dependent Kinase 5 (CDK5)-Mediated Phosphorylation of Upstream Stimulatory Factor 2 (USF2) Contributes to Carcinogenesis |
| title_short | Cyclin-Dependent Kinase 5 (CDK5)-Mediated Phosphorylation of Upstream Stimulatory Factor 2 (USF2) Contributes to Carcinogenesis |
| title_sort | cyclin dependent kinase 5 cdk5 mediated phosphorylation of upstream stimulatory factor 2 usf2 contributes to carcinogenesis |
| topic | upstream stimulatory factor 2 (USF2) cyclin-dependent kinase-5 (CDK5) CRISPR-Cas9 phosphorylation proliferation migration |
| url | https://www.mdpi.com/2072-6694/11/4/523 |
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