Bridging the Bridging Imidazolate in the Bimetallic Center of the Cu/Zn SOD1 and ALS

Bridging the Bridging Imidazolate in the Bimetallic Center of the Cu/Zn SOD1 and ALS

Metallation status of human Cu/Zn superoxide dismutase 1 (SOD1) plays a pivotal role in the pathogenesis of amyotrophic lateral sclerosis (ALS). All of the amino acids found in the bimetallic center have been associated with ALS except for two positions. H63 which forms the bridging imidazolate ion...

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Bibliographic Details
Main Authors: Ahmet Can Timucin, Suleyman Selim Cinaroglu, Osman Ugur Sezerman, Emel Timucin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Chemistry
Subjects:
superoxide dismutase 1
metal binding
molecular dynamics simulation
stabiliy
dimer
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2021.716438/full

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