Detection of sulfane sulfur species in biological systems
Sulfane sulfur species such as hydropersulfides (RSSH), polysulfides (RSnR), and hydrogen polysulfides (H2Sn) are critically involved in sulfur-mediated redox signaling, but their detailed mechanisms of action need further clarification. Therefore, there is a need to develop selective and sensitive...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Redox Biology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231722002749 |
| _version_ | 1811198493285416960 |
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| author | Meg Shieh Shi Xu Oren L. Lederberg Ming Xian |
| author_facet | Meg Shieh Shi Xu Oren L. Lederberg Ming Xian |
| author_sort | Meg Shieh |
| collection | DOAJ |
| description | Sulfane sulfur species such as hydropersulfides (RSSH), polysulfides (RSnR), and hydrogen polysulfides (H2Sn) are critically involved in sulfur-mediated redox signaling, but their detailed mechanisms of action need further clarification. Therefore, there is a need to develop selective and sensitive sulfane sulfur detection methods to gauge a better understanding of their functions. This review summarizes current detection methods that include cyanolysis, chemical derivatization and mass spectrometry, proteomic analysis, fluorescent probes, and resonance synchronous/Raman spectroscopic methods. The design principles, advantages, applications, and limitations of each method are discussed, along with suggested directions for future research on these methods. The development of robust detection methods for sulfane sulfur species will help to elucidate their mechanisms and functions in biological systems. |
| first_indexed | 2024-04-12T01:31:24Z |
| format | Article |
| id | doaj.art-157a7dc8378f4098a9f347e3cf9fdd87 |
| institution | Directory Open Access Journal |
| issn | 2213-2317 |
| language | English |
| last_indexed | 2024-04-12T01:31:24Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Redox Biology |
| spelling | doaj.art-157a7dc8378f4098a9f347e3cf9fdd872022-12-22T03:53:27ZengElsevierRedox Biology2213-23172022-11-0157102502Detection of sulfane sulfur species in biological systemsMeg Shieh0Shi Xu1Oren L. Lederberg2Ming Xian3Department of Chemistry, Brown University, Providence, RI, 02912, USADepartment of Chemistry, Brown University, Providence, RI, 02912, USADepartment of Chemistry, Brown University, Providence, RI, 02912, USACorresponding author.; Department of Chemistry, Brown University, Providence, RI, 02912, USASulfane sulfur species such as hydropersulfides (RSSH), polysulfides (RSnR), and hydrogen polysulfides (H2Sn) are critically involved in sulfur-mediated redox signaling, but their detailed mechanisms of action need further clarification. Therefore, there is a need to develop selective and sensitive sulfane sulfur detection methods to gauge a better understanding of their functions. This review summarizes current detection methods that include cyanolysis, chemical derivatization and mass spectrometry, proteomic analysis, fluorescent probes, and resonance synchronous/Raman spectroscopic methods. The design principles, advantages, applications, and limitations of each method are discussed, along with suggested directions for future research on these methods. The development of robust detection methods for sulfane sulfur species will help to elucidate their mechanisms and functions in biological systems.http://www.sciencedirect.com/science/article/pii/S2213231722002749Sulfane sulfurChemical derivatizationMass spectrometryFluorescence |
| spellingShingle | Meg Shieh Shi Xu Oren L. Lederberg Ming Xian Detection of sulfane sulfur species in biological systems Redox Biology Sulfane sulfur Chemical derivatization Mass spectrometry Fluorescence |
| title | Detection of sulfane sulfur species in biological systems |
| title_full | Detection of sulfane sulfur species in biological systems |
| title_fullStr | Detection of sulfane sulfur species in biological systems |
| title_full_unstemmed | Detection of sulfane sulfur species in biological systems |
| title_short | Detection of sulfane sulfur species in biological systems |
| title_sort | detection of sulfane sulfur species in biological systems |
| topic | Sulfane sulfur Chemical derivatization Mass spectrometry Fluorescence |
| url | http://www.sciencedirect.com/science/article/pii/S2213231722002749 |
| work_keys_str_mv | AT megshieh detectionofsulfanesulfurspeciesinbiologicalsystems AT shixu detectionofsulfanesulfurspeciesinbiologicalsystems AT orenllederberg detectionofsulfanesulfurspeciesinbiologicalsystems AT mingxian detectionofsulfanesulfurspeciesinbiologicalsystems |