Transcriptional Regulation of Amino Acid Transport in Glioblastoma Multiforme

Transcriptional Regulation of Amino Acid Transport in Glioblastoma Multiforme

Glioblastoma multiforme (GBM) is a deadly brain tumor with a large unmet therapeutic need. Here, we tested the hypothesis that wild-type p53 is a negative transcriptional regulator of <i>SLC7A11</i>, the gene encoding the System xc- (SXC) catalytic subunit, xCT, in GBM. We demonstrate th...

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Bibliographic Details
Main Authors: Robyn A. Umans, Joelle Martin, Megan E. Harrigan, Dipan C. Patel, Lata Chaunsali, Aarash Roshandel, Kavya Iyer, Michael D. Powell, Ken Oestreich, Harald Sontheimer
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cancers
Subjects:
glioblastoma multiforme
SLC7A11
p53
glutamate
Online Access:https://www.mdpi.com/2072-6694/13/24/6169

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