A mussel-bioinspired coating strategy to licence PCL osteoinductive activity for repairing bone defects
3,4-Dihydroxyphenylalanine (DOPA) is believed to play an essential role in the solidification and adhesion of liquid mussel adhesives; this thin polymer layer very tightly adheres to the surface of scaffolds, making it stable enough to prevent it from being peeled off. Fascinatingly, the deposition...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-05-01
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| Series: | Journal of Materials Research and Technology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2238785422003714 |
| _version_ | 1819022783608258560 |
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| author | Wentao Shi Zhijia Shen Lu Bian Yan Gao Yiqing Wu Feifei Zhao Hong Tang Xiaojie Lu |
| author_facet | Wentao Shi Zhijia Shen Lu Bian Yan Gao Yiqing Wu Feifei Zhao Hong Tang Xiaojie Lu |
| author_sort | Wentao Shi |
| collection | DOAJ |
| description | 3,4-Dihydroxyphenylalanine (DOPA) is believed to play an essential role in the solidification and adhesion of liquid mussel adhesives; this thin polymer layer very tightly adheres to the surface of scaffolds, making it stable enough to prevent it from being peeled off. Fascinatingly, the deposition of DOPA on various types of surfaces via the self-polymerization of DOPA under alkaline conditions is a simple approach for creating biomimetic coatings. In this study, DOPA derivatives were used as monomers to form primary coatings on polycaprolactone (PCL) surfaces. After that, a second chemical crosslinking method was utilized to graft alendronate (AL) on the DOPA coatings via genipin (GP) crosslinking (D-PCL@AL). X-ray photoelectron spectroscopy, Fourier transform infrared reflection and scanning electron microscopy analyses indicated that AL was distributed homogeneously on the surface of PCL. This new organic–inorganic hybridized coating could support EMSC growth and osteogenic differentiation. Additionally, animal studies were also performed to verify the function of D-PCL@AL in promoting osteogenesis. The method is simple, cheap and highly efficient, which makes it very convenient to apply on a large scale. |
| first_indexed | 2024-12-21T04:28:29Z |
| format | Article |
| id | doaj.art-157b216b5fac47b984774a05d34cb551 |
| institution | Directory Open Access Journal |
| issn | 2238-7854 |
| language | English |
| last_indexed | 2024-12-21T04:28:29Z |
| publishDate | 2022-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Materials Research and Technology |
| spelling | doaj.art-157b216b5fac47b984774a05d34cb5512022-12-21T19:15:59ZengElsevierJournal of Materials Research and Technology2238-78542022-05-011820252036A mussel-bioinspired coating strategy to licence PCL osteoinductive activity for repairing bone defectsWentao Shi0Zhijia Shen1Lu Bian2Yan Gao3Yiqing Wu4Feifei Zhao5Hong Tang6Xiaojie Lu7Jiangnan University Affiliated Hospital, Wuxi, Jiangsu Province, PR China; Nanjing Gaochun People's Hospital, 211300, Nanjing, PR ChinaChangshu Hospital Affiliated to Nanjing University of Chinese Medicine, Changshu, Jiangsu Province, PR ChinaJiangnan University Affiliated Hospital, Wuxi, Jiangsu Province, PR China; Nanjing Gaochun People's Hospital, 211300, Nanjing, PR ChinaJiangnan University Affiliated Hospital, Wuxi, Jiangsu Province, PR ChinaJiangnan University Affiliated Hospital, Wuxi, Jiangsu Province, PR ChinaAffiliated Wuxi Second Hospital, Nanjing Medical University, Wuxi, Jiangsu Province, PR ChinaAffiliated Wuxi Second Hospital, Nanjing Medical University, Wuxi, Jiangsu Province, PR China; Corresponding author.Jiangnan University Affiliated Hospital, Wuxi, Jiangsu Province, PR China; Corresponding author.3,4-Dihydroxyphenylalanine (DOPA) is believed to play an essential role in the solidification and adhesion of liquid mussel adhesives; this thin polymer layer very tightly adheres to the surface of scaffolds, making it stable enough to prevent it from being peeled off. Fascinatingly, the deposition of DOPA on various types of surfaces via the self-polymerization of DOPA under alkaline conditions is a simple approach for creating biomimetic coatings. In this study, DOPA derivatives were used as monomers to form primary coatings on polycaprolactone (PCL) surfaces. After that, a second chemical crosslinking method was utilized to graft alendronate (AL) on the DOPA coatings via genipin (GP) crosslinking (D-PCL@AL). X-ray photoelectron spectroscopy, Fourier transform infrared reflection and scanning electron microscopy analyses indicated that AL was distributed homogeneously on the surface of PCL. This new organic–inorganic hybridized coating could support EMSC growth and osteogenic differentiation. Additionally, animal studies were also performed to verify the function of D-PCL@AL in promoting osteogenesis. The method is simple, cheap and highly efficient, which makes it very convenient to apply on a large scale.http://www.sciencedirect.com/science/article/pii/S2238785422003714PCLDOPAEMSCsCoatingsPiezo 1 |
| spellingShingle | Wentao Shi Zhijia Shen Lu Bian Yan Gao Yiqing Wu Feifei Zhao Hong Tang Xiaojie Lu A mussel-bioinspired coating strategy to licence PCL osteoinductive activity for repairing bone defects Journal of Materials Research and Technology PCL DOPA EMSCs Coatings Piezo 1 |
| title | A mussel-bioinspired coating strategy to licence PCL osteoinductive activity for repairing bone defects |
| title_full | A mussel-bioinspired coating strategy to licence PCL osteoinductive activity for repairing bone defects |
| title_fullStr | A mussel-bioinspired coating strategy to licence PCL osteoinductive activity for repairing bone defects |
| title_full_unstemmed | A mussel-bioinspired coating strategy to licence PCL osteoinductive activity for repairing bone defects |
| title_short | A mussel-bioinspired coating strategy to licence PCL osteoinductive activity for repairing bone defects |
| title_sort | mussel bioinspired coating strategy to licence pcl osteoinductive activity for repairing bone defects |
| topic | PCL DOPA EMSCs Coatings Piezo 1 |
| url | http://www.sciencedirect.com/science/article/pii/S2238785422003714 |
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