Tracking Clonal Evolution of Multiple Myeloma Using Targeted Next-Generation DNA Sequencing

Tracking Clonal Evolution of Multiple Myeloma Using Targeted Next-Generation DNA Sequencing

Clonal evolution drives treatment failure in multiple myeloma (MM). Here, we used a custom 372-gene panel to track genetic changes occurring during MM progression at different stages of the disease. A tumor-only targeted next-generation DNA sequencing was performed on 69 samples sequentially collect...

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Bibliographic Details
Main Authors: Aleksander Salomon-Perzyński, Joanna Barankiewicz, Marcin Machnicki, Irena Misiewicz-Krzemińska, Michał Pawlak, Sylwia Radomska, Agnieszka Krzywdzińska, Aleksandra Bluszcz, Piotr Stawiński, Małgorzata Rydzanicz, Natalia Jakacka, Iwona Solarska, Katarzyna Borg, Zofia Spyra-Górny, Tomasz Szpila, Bartosz Puła, Sebastian Grosicki, Tomasz Stokłosa, Rafał Płoski, Ewa Lech-Marańda, Jana Jakubikova, Krzysztof Jamroziak
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Biomedicines
Subjects:
clonal evolution
multiple myeloma
next-generation sequencing
Online Access:https://www.mdpi.com/2227-9059/10/7/1674

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