PAN-cancer analysis of S-phase enriched lncRNAs identifies oncogenic drivers and biomarkers

PAN-cancer analysis of S-phase enriched lncRNAs identifies oncogenic drivers and biomarkers

Although we know lncRNAs play a role in cancer, the identification of clinically relevant and functional lncRNAs is lacking. Here, the authors identify 633 prognostic markers, 570 S-phase cancer-associated lncRNAs, and show SCAT7 regulates FGF/FGFR and PI3K/AKT/MAPK pathways via interaction with hnR...

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Bibliographic Details
Main Authors: Mohamad Moustafa Ali, Vijay Suresh Akhade, Subazini Thankaswamy Kosalai, Santhilal Subhash, Luisa Statello, Matthieu Meryet-Figuiere, Jonas Abrahamsson, Tanmoy Mondal, Chandrasekhar Kanduri
Format: Article
Language:English
Published: Nature Portfolio 2018-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03265-1
Description
Summary:Although we know lncRNAs play a role in cancer, the identification of clinically relevant and functional lncRNAs is lacking. Here, the authors identify 633 prognostic markers, 570 S-phase cancer-associated lncRNAs, and show SCAT7 regulates FGF/FGFR and PI3K/AKT/MAPK pathways via interaction with hnRNPK/YBX1 complexes.
ISSN:2041-1723

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