PAN-cancer analysis of S-phase enriched lncRNAs identifies oncogenic drivers and biomarkers
Although we know lncRNAs play a role in cancer, the identification of clinically relevant and functional lncRNAs is lacking. Here, the authors identify 633 prognostic markers, 570 S-phase cancer-associated lncRNAs, and show SCAT7 regulates FGF/FGFR and PI3K/AKT/MAPK pathways via interaction with hnR...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-03265-1 |
| _version_ | 1818750529313964032 |
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| author | Mohamad Moustafa Ali Vijay Suresh Akhade Subazini Thankaswamy Kosalai Santhilal Subhash Luisa Statello Matthieu Meryet-Figuiere Jonas Abrahamsson Tanmoy Mondal Chandrasekhar Kanduri |
| author_facet | Mohamad Moustafa Ali Vijay Suresh Akhade Subazini Thankaswamy Kosalai Santhilal Subhash Luisa Statello Matthieu Meryet-Figuiere Jonas Abrahamsson Tanmoy Mondal Chandrasekhar Kanduri |
| author_sort | Mohamad Moustafa Ali |
| collection | DOAJ |
| description | Although we know lncRNAs play a role in cancer, the identification of clinically relevant and functional lncRNAs is lacking. Here, the authors identify 633 prognostic markers, 570 S-phase cancer-associated lncRNAs, and show SCAT7 regulates FGF/FGFR and PI3K/AKT/MAPK pathways via interaction with hnRNPK/YBX1 complexes. |
| first_indexed | 2024-12-18T04:21:07Z |
| format | Article |
| id | doaj.art-157be40b73b2441180be0273025f743a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T04:21:07Z |
| publishDate | 2018-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-157be40b73b2441180be0273025f743a2022-12-21T21:21:14ZengNature PortfolioNature Communications2041-17232018-02-019112010.1038/s41467-018-03265-1PAN-cancer analysis of S-phase enriched lncRNAs identifies oncogenic drivers and biomarkersMohamad Moustafa Ali0Vijay Suresh Akhade1Subazini Thankaswamy Kosalai2Santhilal Subhash3Luisa Statello4Matthieu Meryet-Figuiere5Jonas Abrahamsson6Tanmoy Mondal7Chandrasekhar Kanduri8Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of GothenburgDepartment of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of GothenburgDepartment of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of GothenburgDepartment of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of GothenburgDepartment of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of GothenburgDepartment of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of GothenburgDepartment of Pediatrics, Institution for Clinical Sciences, Sahlgrenska Academy, University of GothenburgDepartment of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of GothenburgDepartment of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of GothenburgAlthough we know lncRNAs play a role in cancer, the identification of clinically relevant and functional lncRNAs is lacking. Here, the authors identify 633 prognostic markers, 570 S-phase cancer-associated lncRNAs, and show SCAT7 regulates FGF/FGFR and PI3K/AKT/MAPK pathways via interaction with hnRNPK/YBX1 complexes.https://doi.org/10.1038/s41467-018-03265-1 |
| spellingShingle | Mohamad Moustafa Ali Vijay Suresh Akhade Subazini Thankaswamy Kosalai Santhilal Subhash Luisa Statello Matthieu Meryet-Figuiere Jonas Abrahamsson Tanmoy Mondal Chandrasekhar Kanduri PAN-cancer analysis of S-phase enriched lncRNAs identifies oncogenic drivers and biomarkers Nature Communications |
| title | PAN-cancer analysis of S-phase enriched lncRNAs identifies oncogenic drivers and biomarkers |
| title_full | PAN-cancer analysis of S-phase enriched lncRNAs identifies oncogenic drivers and biomarkers |
| title_fullStr | PAN-cancer analysis of S-phase enriched lncRNAs identifies oncogenic drivers and biomarkers |
| title_full_unstemmed | PAN-cancer analysis of S-phase enriched lncRNAs identifies oncogenic drivers and biomarkers |
| title_short | PAN-cancer analysis of S-phase enriched lncRNAs identifies oncogenic drivers and biomarkers |
| title_sort | pan cancer analysis of s phase enriched lncrnas identifies oncogenic drivers and biomarkers |
| url | https://doi.org/10.1038/s41467-018-03265-1 |
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