Exercise Training Increases Parietal Lobe Cerebral Blood Flow in Chronic Stroke: An Observational Study
Exercise is increasingly recommended as an essential component of stroke rehabilitation, yet uncertainty remains with respect to its direct effect on the cerebral vasculature. The current study first demonstrated the repeatability of pseudo-continuous arterial spin labeling (ASL) magnetic resonance...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-09-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fnagi.2017.00318/full |
| _version_ | 1818272494973353984 |
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| author | Andrew D. Robertson Andrew D. Robertson Susan Marzolini Susan Marzolini Laura E. Middleton Laura E. Middleton Vincenzo S. Basile Paul I. Oh Paul I. Oh Paul I. Oh Bradley J. MacIntosh Bradley J. MacIntosh |
| author_facet | Andrew D. Robertson Andrew D. Robertson Susan Marzolini Susan Marzolini Laura E. Middleton Laura E. Middleton Vincenzo S. Basile Paul I. Oh Paul I. Oh Paul I. Oh Bradley J. MacIntosh Bradley J. MacIntosh |
| author_sort | Andrew D. Robertson |
| collection | DOAJ |
| description | Exercise is increasingly recommended as an essential component of stroke rehabilitation, yet uncertainty remains with respect to its direct effect on the cerebral vasculature. The current study first demonstrated the repeatability of pseudo-continuous arterial spin labeling (ASL) magnetic resonance imaging (MRI) in older adults with stroke, and then investigated the change in cerebrovascular function following a 6-month cardiovascular rehabilitation program. In the repeatability study, 12 participants at least 3 months post-stroke underwent two ASL imaging scans 1 month apart. In the prospective observational study, eight individuals underwent ASL imaging and aerobic fitness testing before and after a 6-month cardiovascular rehabilitation program. Cerebral blood flow (CBF) and the spatial coefficient of variation of CBF (sCoV) were quantified to characterize tissue-level perfusion and large cerebral artery transit time properties, respectively. In repeat scanning, intraclass correlation (ICC) indicated moderate test-retest reliability for global gray matter CBF (ICC = 0.73) and excellent reliability for sCoV (ICC = 0.94). In the observational study, gray matter CBF increased after training (baseline: 40 ± 13 vs. 6-month: 46 ± 12 ml·100 g−1·min−1, P = 0.036). The greatest change occurred in the parietal lobe (+18 ± 12%). Gray matter sCoV, however, did not change following training (P = 0.31). This study provides preliminary evidence that exercise-based rehabilitation in chronic stroke enhances tissue-level perfusion, without changing the relative hemodynamic properties of the large cerebral arteries. |
| first_indexed | 2024-12-12T21:42:58Z |
| format | Article |
| id | doaj.art-157ec1edf19c40a48621ce1668469639 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-12T21:42:58Z |
| publishDate | 2017-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-157ec1edf19c40a48621ce16684696392022-12-22T00:10:59ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652017-09-01910.3389/fnagi.2017.00318292789Exercise Training Increases Parietal Lobe Cerebral Blood Flow in Chronic Stroke: An Observational StudyAndrew D. Robertson0Andrew D. Robertson1Susan Marzolini2Susan Marzolini3Laura E. Middleton4Laura E. Middleton5Vincenzo S. Basile6Paul I. Oh7Paul I. Oh8Paul I. Oh9Bradley J. MacIntosh10Bradley J. MacIntosh11Heart and Stroke Foundation Canadian Partnership for Stroke Recovery, Ottawa, ON, CanadaHurvitz Brain Sciences, Sunnybrook Research Institute, University of Toronto, Toronto, ON, CanadaHeart and Stroke Foundation Canadian Partnership for Stroke Recovery, Ottawa, ON, CanadaToronto Rehab, University Health Network, Toronto, ON, CanadaHeart and Stroke Foundation Canadian Partnership for Stroke Recovery, Ottawa, ON, CanadaDepartment of Kinesiology, University of Waterloo, Waterloo, ON, CanadaDivision of Neurology, Mackenzie Health, Richmond Hill, ON, CanadaHeart and Stroke Foundation Canadian Partnership for Stroke Recovery, Ottawa, ON, CanadaToronto Rehab, University Health Network, Toronto, ON, CanadaPeter Munk Cardiac Centre, University of Toronto, Toronto, ON, CanadaHeart and Stroke Foundation Canadian Partnership for Stroke Recovery, Ottawa, ON, CanadaHurvitz Brain Sciences, Sunnybrook Research Institute, University of Toronto, Toronto, ON, CanadaExercise is increasingly recommended as an essential component of stroke rehabilitation, yet uncertainty remains with respect to its direct effect on the cerebral vasculature. The current study first demonstrated the repeatability of pseudo-continuous arterial spin labeling (ASL) magnetic resonance imaging (MRI) in older adults with stroke, and then investigated the change in cerebrovascular function following a 6-month cardiovascular rehabilitation program. In the repeatability study, 12 participants at least 3 months post-stroke underwent two ASL imaging scans 1 month apart. In the prospective observational study, eight individuals underwent ASL imaging and aerobic fitness testing before and after a 6-month cardiovascular rehabilitation program. Cerebral blood flow (CBF) and the spatial coefficient of variation of CBF (sCoV) were quantified to characterize tissue-level perfusion and large cerebral artery transit time properties, respectively. In repeat scanning, intraclass correlation (ICC) indicated moderate test-retest reliability for global gray matter CBF (ICC = 0.73) and excellent reliability for sCoV (ICC = 0.94). In the observational study, gray matter CBF increased after training (baseline: 40 ± 13 vs. 6-month: 46 ± 12 ml·100 g−1·min−1, P = 0.036). The greatest change occurred in the parietal lobe (+18 ± 12%). Gray matter sCoV, however, did not change following training (P = 0.31). This study provides preliminary evidence that exercise-based rehabilitation in chronic stroke enhances tissue-level perfusion, without changing the relative hemodynamic properties of the large cerebral arteries.http://journal.frontiersin.org/article/10.3389/fnagi.2017.00318/fullaerobic exercisearterial spin labelingcerebrovascular circulationcerebrovascular diseaserehabilitation |
| spellingShingle | Andrew D. Robertson Andrew D. Robertson Susan Marzolini Susan Marzolini Laura E. Middleton Laura E. Middleton Vincenzo S. Basile Paul I. Oh Paul I. Oh Paul I. Oh Bradley J. MacIntosh Bradley J. MacIntosh Exercise Training Increases Parietal Lobe Cerebral Blood Flow in Chronic Stroke: An Observational Study Frontiers in Aging Neuroscience aerobic exercise arterial spin labeling cerebrovascular circulation cerebrovascular disease rehabilitation |
| title | Exercise Training Increases Parietal Lobe Cerebral Blood Flow in Chronic Stroke: An Observational Study |
| title_full | Exercise Training Increases Parietal Lobe Cerebral Blood Flow in Chronic Stroke: An Observational Study |
| title_fullStr | Exercise Training Increases Parietal Lobe Cerebral Blood Flow in Chronic Stroke: An Observational Study |
| title_full_unstemmed | Exercise Training Increases Parietal Lobe Cerebral Blood Flow in Chronic Stroke: An Observational Study |
| title_short | Exercise Training Increases Parietal Lobe Cerebral Blood Flow in Chronic Stroke: An Observational Study |
| title_sort | exercise training increases parietal lobe cerebral blood flow in chronic stroke an observational study |
| topic | aerobic exercise arterial spin labeling cerebrovascular circulation cerebrovascular disease rehabilitation |
| url | http://journal.frontiersin.org/article/10.3389/fnagi.2017.00318/full |
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