Roles of sex hormones in mediating the causal effect of vitamin D on osteoporosis: A two-step Mendelian randomization study

Roles of sex hormones in mediating the causal effect of vitamin D on osteoporosis: A two-step Mendelian randomization study

BackgroundAlthough 25-hydroxyvitamin D [25(OH)D] is a risk factor for osteoporosis, it is not clear whether sex hormones mediate this casual association. We aimed to explore how sex hormones affect the association between 25(OH)D and osteoporosis to provide meaningful insights on the underlying mech...

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Bibliographic Details
Main Authors: Yongwei Du, Baohui Xie, Maoyuan Wang, Yanbiao Zhong, Zhimai Lv, Yun Luo, Qiwei He, Zhen Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Endocrinology
Subjects:
osteoporosis
vitamin D
sex hormone
Mendelian randomization
causality
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1159241/full

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