Efficacy of enalapril in migraine prophylaxis: A randomized, double-blind, placebo-controlled trial
Background: Some angiotensin converting enzyme (ACE) inhibitors have previously been shown to be effective in migraine prophylaxis. The aim of this study was to evaluate whether Enalapril is effective in migraine prophylaxis. Methods: In this randomized, double-blind, placebo-controlled clinical tri...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2013-01-01
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| Series: | International Journal of Preventive Medicine |
| Subjects: | |
| Online Access: | http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2013;volume=4;issue=1;spage=72;epage=77;aulast=Sonbolestan |
| _version_ | 1818252570109411328 |
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| author | Seyed Ali Sonbolestan Kiyan Heshmat Shaghayegh Haghjooy Javanmard Mohammad Saadatnia |
| author_facet | Seyed Ali Sonbolestan Kiyan Heshmat Shaghayegh Haghjooy Javanmard Mohammad Saadatnia |
| author_sort | Seyed Ali Sonbolestan |
| collection | DOAJ |
| description | Background: Some angiotensin converting enzyme (ACE) inhibitors have previously been shown to be effective in migraine prophylaxis. The aim of this study was to evaluate whether Enalapril is effective in migraine prophylaxis.
Methods: In this randomized, double-blind, placebo-controlled clinical trial, the effects of 10 mg Enalapril given daily were compared with those of matched placebo in 40 migraineurs for 2 months. Response to treatment was assessed at 0, 1, and 2 months after the start of intervention according to headache parameters like frequency, severity, and duration. This trial is registered with Iranian Registry of Clinical Trials (IRCT), number IRCT138711011570N1.
Results: A significant effect on reducing migraine attack more than 50% at first and second months (P=0.016) occurred in Enalapril group. Indeed, at the first and second months of treatment, the severities (P=0.000 and P=0.000) and duration (P=0.037 and 0.003) in the Enalapril treated group were significantly lower than in the placebo group.
Conclusion: Enalapril may be effective in migraine prophylaxis according to its effect in decreasing the frequency, severity, and duration of headaches. The results support the previous suggestions on usage of ACE inhibitors in migraine prophylaxis. |
| first_indexed | 2024-12-12T16:26:16Z |
| format | Article |
| id | doaj.art-15804096b623405ab09080b3e80388e5 |
| institution | Directory Open Access Journal |
| issn | 2008-7802 2008-8213 |
| language | English |
| last_indexed | 2024-12-12T16:26:16Z |
| publishDate | 2013-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | International Journal of Preventive Medicine |
| spelling | doaj.art-15804096b623405ab09080b3e80388e52022-12-22T00:18:52ZengWolters Kluwer Medknow PublicationsInternational Journal of Preventive Medicine2008-78022008-82132013-01-01417277Efficacy of enalapril in migraine prophylaxis: A randomized, double-blind, placebo-controlled trialSeyed Ali SonbolestanKiyan HeshmatShaghayegh Haghjooy JavanmardMohammad SaadatniaBackground: Some angiotensin converting enzyme (ACE) inhibitors have previously been shown to be effective in migraine prophylaxis. The aim of this study was to evaluate whether Enalapril is effective in migraine prophylaxis. Methods: In this randomized, double-blind, placebo-controlled clinical trial, the effects of 10 mg Enalapril given daily were compared with those of matched placebo in 40 migraineurs for 2 months. Response to treatment was assessed at 0, 1, and 2 months after the start of intervention according to headache parameters like frequency, severity, and duration. This trial is registered with Iranian Registry of Clinical Trials (IRCT), number IRCT138711011570N1. Results: A significant effect on reducing migraine attack more than 50% at first and second months (P=0.016) occurred in Enalapril group. Indeed, at the first and second months of treatment, the severities (P=0.000 and P=0.000) and duration (P=0.037 and 0.003) in the Enalapril treated group were significantly lower than in the placebo group. Conclusion: Enalapril may be effective in migraine prophylaxis according to its effect in decreasing the frequency, severity, and duration of headaches. The results support the previous suggestions on usage of ACE inhibitors in migraine prophylaxis.http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2013;volume=4;issue=1;spage=72;epage=77;aulast=SonbolestanAngiotensin converting enzyme inhibitorsEnalaprilmigraine disorders |
| spellingShingle | Seyed Ali Sonbolestan Kiyan Heshmat Shaghayegh Haghjooy Javanmard Mohammad Saadatnia Efficacy of enalapril in migraine prophylaxis: A randomized, double-blind, placebo-controlled trial International Journal of Preventive Medicine Angiotensin converting enzyme inhibitors Enalapril migraine disorders |
| title | Efficacy of enalapril in migraine prophylaxis: A randomized, double-blind, placebo-controlled trial |
| title_full | Efficacy of enalapril in migraine prophylaxis: A randomized, double-blind, placebo-controlled trial |
| title_fullStr | Efficacy of enalapril in migraine prophylaxis: A randomized, double-blind, placebo-controlled trial |
| title_full_unstemmed | Efficacy of enalapril in migraine prophylaxis: A randomized, double-blind, placebo-controlled trial |
| title_short | Efficacy of enalapril in migraine prophylaxis: A randomized, double-blind, placebo-controlled trial |
| title_sort | efficacy of enalapril in migraine prophylaxis a randomized double blind placebo controlled trial |
| topic | Angiotensin converting enzyme inhibitors Enalapril migraine disorders |
| url | http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2013;volume=4;issue=1;spage=72;epage=77;aulast=Sonbolestan |
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