CTCF and Its Multi-Partner Network for Chromatin Regulation
Architectural proteins are essential epigenetic regulators that play a critical role in organizing chromatin and controlling gene expression. CTCF (CCCTC-binding factor) is a key architectural protein responsible for maintaining the intricate 3D structure of chromatin. Because of its multivalent pro...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/10/1357 |
| _version_ | 1797600617584132096 |
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| author | Aylin Del Moral-Morales Marisol Salgado-Albarrán Yesennia Sánchez-Pérez Nina Kerstin Wenke Jan Baumbach Ernesto Soto-Reyes |
| author_facet | Aylin Del Moral-Morales Marisol Salgado-Albarrán Yesennia Sánchez-Pérez Nina Kerstin Wenke Jan Baumbach Ernesto Soto-Reyes |
| author_sort | Aylin Del Moral-Morales |
| collection | DOAJ |
| description | Architectural proteins are essential epigenetic regulators that play a critical role in organizing chromatin and controlling gene expression. CTCF (CCCTC-binding factor) is a key architectural protein responsible for maintaining the intricate 3D structure of chromatin. Because of its multivalent properties and plasticity to bind various sequences, CTCF is similar to a Swiss knife for genome organization. Despite the importance of this protein, its mechanisms of action are not fully elucidated. It has been hypothesized that its versatility is achieved through interaction with multiple partners, forming a complex network that regulates chromatin folding within the nucleus. In this review, we delve into CTCF’s interactions with other molecules involved in epigenetic processes, particularly histone and DNA demethylases, as well as several long non-coding RNAs (lncRNAs) that are able to recruit CTCF. Our review highlights the importance of CTCF partners to shed light on chromatin regulation and pave the way for future exploration of the mechanisms that enable the finely-tuned role of CTCF as a master regulator of chromatin. |
| first_indexed | 2024-03-11T03:51:22Z |
| format | Article |
| id | doaj.art-15809eb4c25047d6a50bd975e7a1b6cb |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T03:51:22Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-15809eb4c25047d6a50bd975e7a1b6cb2023-11-18T00:52:24ZengMDPI AGCells2073-44092023-05-011210135710.3390/cells12101357CTCF and Its Multi-Partner Network for Chromatin RegulationAylin Del Moral-Morales0Marisol Salgado-Albarrán1Yesennia Sánchez-Pérez2Nina Kerstin Wenke3Jan Baumbach4Ernesto Soto-Reyes5Departamento de Ciencias Naturales, Universidad Autónoma Metropolitana-Cuajimalpa (UAM-C), Mexico City 05348, MexicoDepartamento de Ciencias Naturales, Universidad Autónoma Metropolitana-Cuajimalpa (UAM-C), Mexico City 05348, MexicoSubdirección de Investigación, Instituto Nacional de Cancerología, Mexico City 14080, MexicoInstitute for Computational Systems Biology, University of Hamburg, D-22607 Hamburg, GermanyInstitute for Computational Systems Biology, University of Hamburg, D-22607 Hamburg, GermanyDepartamento de Ciencias Naturales, Universidad Autónoma Metropolitana-Cuajimalpa (UAM-C), Mexico City 05348, MexicoArchitectural proteins are essential epigenetic regulators that play a critical role in organizing chromatin and controlling gene expression. CTCF (CCCTC-binding factor) is a key architectural protein responsible for maintaining the intricate 3D structure of chromatin. Because of its multivalent properties and plasticity to bind various sequences, CTCF is similar to a Swiss knife for genome organization. Despite the importance of this protein, its mechanisms of action are not fully elucidated. It has been hypothesized that its versatility is achieved through interaction with multiple partners, forming a complex network that regulates chromatin folding within the nucleus. In this review, we delve into CTCF’s interactions with other molecules involved in epigenetic processes, particularly histone and DNA demethylases, as well as several long non-coding RNAs (lncRNAs) that are able to recruit CTCF. Our review highlights the importance of CTCF partners to shed light on chromatin regulation and pave the way for future exploration of the mechanisms that enable the finely-tuned role of CTCF as a master regulator of chromatin.https://www.mdpi.com/2073-4409/12/10/1357CTCFepigeneticschromatin regulationhistonedemethylaseslncRNAs |
| spellingShingle | Aylin Del Moral-Morales Marisol Salgado-Albarrán Yesennia Sánchez-Pérez Nina Kerstin Wenke Jan Baumbach Ernesto Soto-Reyes CTCF and Its Multi-Partner Network for Chromatin Regulation Cells CTCF epigenetics chromatin regulation histone demethylases lncRNAs |
| title | CTCF and Its Multi-Partner Network for Chromatin Regulation |
| title_full | CTCF and Its Multi-Partner Network for Chromatin Regulation |
| title_fullStr | CTCF and Its Multi-Partner Network for Chromatin Regulation |
| title_full_unstemmed | CTCF and Its Multi-Partner Network for Chromatin Regulation |
| title_short | CTCF and Its Multi-Partner Network for Chromatin Regulation |
| title_sort | ctcf and its multi partner network for chromatin regulation |
| topic | CTCF epigenetics chromatin regulation histone demethylases lncRNAs |
| url | https://www.mdpi.com/2073-4409/12/10/1357 |
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