Probing of Interactions of Magnetite Nanoparticles Coated with Native and Aminated Starch with a DPPC Model Membrane
Understanding the mechanism of interactions between magnetite nanoparticles and phospholipids that form cellular membranes at the molecular level is of crucial importance for their safe and effective application in medicine (e.g., magnetic resonance imaging, targeted drug delivery, and hyperthermia-...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/11/5939 |
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| author | Emilia Piosik Aleksandra Zaryczniak Kinga Mylkie Marta Ziegler-Borowska |
| author_facet | Emilia Piosik Aleksandra Zaryczniak Kinga Mylkie Marta Ziegler-Borowska |
| author_sort | Emilia Piosik |
| collection | DOAJ |
| description | Understanding the mechanism of interactions between magnetite nanoparticles and phospholipids that form cellular membranes at the molecular level is of crucial importance for their safe and effective application in medicine (e.g., magnetic resonance imaging, targeted drug delivery, and hyperthermia-based anticancer therapy). In these interactions, their surface coating plays a crucial role because even a small modification to its structure can cause significant changes to the behaviour of the magnetite nanoparticles that come in contact with a biomembrane. In this work, the influence of the magnetite nanoparticles functionalized with native and aminated starch on the thermodynamics, morphology, and dilatational elasticity of the model cell membranes was studied. The model cell membranes constituted the Langmuir monolayers formed at the air–water interface of dipalmitoylphosphatidylcholine (DPPC). The surface of the aminated starch-coated nanoparticles was enriched in highly reactive amino groups, which allowed more effective binding of drugs and biomolecules suitable for specific nano–bio applications. The studies indicated that the presence of these groups also reduced to some extent the disruptive effect of the magnetite nanoparticles on the model membranes and improved their adsorption. |
| first_indexed | 2024-03-10T10:49:28Z |
| format | Article |
| id | doaj.art-15812494f3f14b0fb91f41f98315f022 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T10:49:28Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-15812494f3f14b0fb91f41f98315f0222023-11-21T22:19:17ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-05-012211593910.3390/ijms22115939Probing of Interactions of Magnetite Nanoparticles Coated with Native and Aminated Starch with a DPPC Model MembraneEmilia Piosik0Aleksandra Zaryczniak1Kinga Mylkie2Marta Ziegler-Borowska3Faculty of Material Engineering and Technical Physics, Poznan University of Technology, Piotrowo 3, 60-965 Poznan, PolandFaculty of Material Engineering and Technical Physics, Poznan University of Technology, Piotrowo 3, 60-965 Poznan, PolandFaculty of Chemistry, Nicolaus Copernicus University in Torun, Gagarina 7, 87-100 Torun, PolandFaculty of Chemistry, Nicolaus Copernicus University in Torun, Gagarina 7, 87-100 Torun, PolandUnderstanding the mechanism of interactions between magnetite nanoparticles and phospholipids that form cellular membranes at the molecular level is of crucial importance for their safe and effective application in medicine (e.g., magnetic resonance imaging, targeted drug delivery, and hyperthermia-based anticancer therapy). In these interactions, their surface coating plays a crucial role because even a small modification to its structure can cause significant changes to the behaviour of the magnetite nanoparticles that come in contact with a biomembrane. In this work, the influence of the magnetite nanoparticles functionalized with native and aminated starch on the thermodynamics, morphology, and dilatational elasticity of the model cell membranes was studied. The model cell membranes constituted the Langmuir monolayers formed at the air–water interface of dipalmitoylphosphatidylcholine (DPPC). The surface of the aminated starch-coated nanoparticles was enriched in highly reactive amino groups, which allowed more effective binding of drugs and biomolecules suitable for specific nano–bio applications. The studies indicated that the presence of these groups also reduced to some extent the disruptive effect of the magnetite nanoparticles on the model membranes and improved their adsorption.https://www.mdpi.com/1422-0067/22/11/5939magnetite nanoparticlesstarchaminated starchcell membraneLangmuir filmnanomedicine |
| spellingShingle | Emilia Piosik Aleksandra Zaryczniak Kinga Mylkie Marta Ziegler-Borowska Probing of Interactions of Magnetite Nanoparticles Coated with Native and Aminated Starch with a DPPC Model Membrane International Journal of Molecular Sciences magnetite nanoparticles starch aminated starch cell membrane Langmuir film nanomedicine |
| title | Probing of Interactions of Magnetite Nanoparticles Coated with Native and Aminated Starch with a DPPC Model Membrane |
| title_full | Probing of Interactions of Magnetite Nanoparticles Coated with Native and Aminated Starch with a DPPC Model Membrane |
| title_fullStr | Probing of Interactions of Magnetite Nanoparticles Coated with Native and Aminated Starch with a DPPC Model Membrane |
| title_full_unstemmed | Probing of Interactions of Magnetite Nanoparticles Coated with Native and Aminated Starch with a DPPC Model Membrane |
| title_short | Probing of Interactions of Magnetite Nanoparticles Coated with Native and Aminated Starch with a DPPC Model Membrane |
| title_sort | probing of interactions of magnetite nanoparticles coated with native and aminated starch with a dppc model membrane |
| topic | magnetite nanoparticles starch aminated starch cell membrane Langmuir film nanomedicine |
| url | https://www.mdpi.com/1422-0067/22/11/5939 |
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