CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma

CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma

Abstract Background Long non-coding RNAs (lncRNAs) exhibit highly cell type-specific expression and function, making this class of transcript attractive for targeted cancer therapy. However, the vast majority of lncRNAs have not been tested as potential therapeutic targets, particularly in the conte...

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Main Authors: S. John Liu, Martina Malatesta, Brian V. Lien, Parna Saha, Shivani S. Thombare, Sung Jun Hong, Leslie Pedraza, Mark Koontz, Kyounghee Seo, Max A. Horlbeck, Daniel He, Harjus S. Birk, Miten Jain, Hugh E. Olsen, Mark Akeson, Jonathan S. Weissman, Michelle Monje, Nalin Gupta, David R. Raleigh, Erik M. Ullian, Daniel A. Lim
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Genome Biology
Subjects:
CRISPRi
lncRNA
Organoids
Radiation
Glioma
Cancer therapy
Online Access:http://link.springer.com/article/10.1186/s13059-020-01995-4

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