CURRENT CANCER STEM CELL BIOMARKERS IN TONGUE SQUAMOUS CELL CARCINOMA
Tongue squamous cell carcinoma (TSCC) is known to be the most malignant cancer type amongst other oral cancers with increasing incidence and mortality rates in the past five years. Since the life expectancy for TSCC patients is limited and the current chemo-radiotherapy treatments are not curative,...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Trakya University
2018-10-01
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| Series: | Trakya University Journal of Natural Sciences |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/en/download/article-file/485414 |
| _version_ | 1797633849762512896 |
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| author | Omer Faruk Karatas Seyma Teber Ahmet Yilmaz Asli Baltacioglu Selinay Merve Kilic Emel Poyraz Abdulmelik Aytatli Sumeyye Ozturk Ayse Varol |
| author_facet | Omer Faruk Karatas Seyma Teber Ahmet Yilmaz Asli Baltacioglu Selinay Merve Kilic Emel Poyraz Abdulmelik Aytatli Sumeyye Ozturk Ayse Varol |
| author_sort | Omer Faruk Karatas |
| collection | DOAJ |
| description | Tongue squamous cell carcinoma (TSCC) is known to be the most malignant
cancer type amongst other oral cancers with increasing incidence and mortality
rates in the past five years. Since the life expectancy for TSCC patients is
limited and the current chemo-radiotherapy treatments are not curative, novel
biomarkers are urgently needed. As many other solid tumors, TSCC has a heterogeneous
cancer cell population, which includes a small subpopulation identified as
cancer stem cells (CSCs) that are considered as the driving force for tumor
initiation, development, spread, recurrence, and resistance to
chemo-radiotherapy. Although the underlying molecular mechanisms of how CSCs
are involved in the carcinogenesis are not completely understood, scientists
and clinicians aim to utilize those cells as therapeutic tools in fight against
different cancer types including TSCC. Here, we reviewed and summarized
important findings and the most current literature to shed light on the
potential of cancer stem cells markers in TSCC. Possible functions of CSCs
biomarkers in TSCC pathogenesis during cancer initiation, progression, invasion
or metastasis are also summarized. |
| first_indexed | 2024-03-11T12:00:25Z |
| format | Article |
| id | doaj.art-158153db83b84f86a0fb98ccbfd7e2ed |
| institution | Directory Open Access Journal |
| issn | 2528-9691 |
| language | English |
| last_indexed | 2024-03-11T12:00:25Z |
| publishDate | 2018-10-01 |
| publisher | Trakya University |
| record_format | Article |
| series | Trakya University Journal of Natural Sciences |
| spelling | doaj.art-158153db83b84f86a0fb98ccbfd7e2ed2023-11-08T07:27:56ZengTrakya UniversityTrakya University Journal of Natural Sciences2528-96912018-10-0119219720710.23902/trkjnat.36882969CURRENT CANCER STEM CELL BIOMARKERS IN TONGUE SQUAMOUS CELL CARCINOMAOmer Faruk KaratasSeyma TeberAhmet YilmazAsli BaltaciogluSelinay Merve KilicEmel PoyrazAbdulmelik AytatliSumeyye OzturkAyse VarolTongue squamous cell carcinoma (TSCC) is known to be the most malignant cancer type amongst other oral cancers with increasing incidence and mortality rates in the past five years. Since the life expectancy for TSCC patients is limited and the current chemo-radiotherapy treatments are not curative, novel biomarkers are urgently needed. As many other solid tumors, TSCC has a heterogeneous cancer cell population, which includes a small subpopulation identified as cancer stem cells (CSCs) that are considered as the driving force for tumor initiation, development, spread, recurrence, and resistance to chemo-radiotherapy. Although the underlying molecular mechanisms of how CSCs are involved in the carcinogenesis are not completely understood, scientists and clinicians aim to utilize those cells as therapeutic tools in fight against different cancer types including TSCC. Here, we reviewed and summarized important findings and the most current literature to shed light on the potential of cancer stem cells markers in TSCC. Possible functions of CSCs biomarkers in TSCC pathogenesis during cancer initiation, progression, invasion or metastasis are also summarized.https://dergipark.org.tr/en/download/article-file/485414tongue squamous cell carcinomacancer stem cellbiomarkercancer stem cellbiomarkertongue squamous cell carcinoma |
| spellingShingle | Omer Faruk Karatas Seyma Teber Ahmet Yilmaz Asli Baltacioglu Selinay Merve Kilic Emel Poyraz Abdulmelik Aytatli Sumeyye Ozturk Ayse Varol CURRENT CANCER STEM CELL BIOMARKERS IN TONGUE SQUAMOUS CELL CARCINOMA Trakya University Journal of Natural Sciences tongue squamous cell carcinoma cancer stem cell biomarker cancer stem cell biomarker tongue squamous cell carcinoma |
| title | CURRENT CANCER STEM CELL BIOMARKERS IN TONGUE SQUAMOUS CELL CARCINOMA |
| title_full | CURRENT CANCER STEM CELL BIOMARKERS IN TONGUE SQUAMOUS CELL CARCINOMA |
| title_fullStr | CURRENT CANCER STEM CELL BIOMARKERS IN TONGUE SQUAMOUS CELL CARCINOMA |
| title_full_unstemmed | CURRENT CANCER STEM CELL BIOMARKERS IN TONGUE SQUAMOUS CELL CARCINOMA |
| title_short | CURRENT CANCER STEM CELL BIOMARKERS IN TONGUE SQUAMOUS CELL CARCINOMA |
| title_sort | current cancer stem cell biomarkers in tongue squamous cell carcinoma |
| topic | tongue squamous cell carcinoma cancer stem cell biomarker cancer stem cell biomarker tongue squamous cell carcinoma |
| url | https://dergipark.org.tr/en/download/article-file/485414 |
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