Photochemotherapy For Widespread Psoriasis
Forty live psoriatics (40 chronic plaque, 5 stable erythrodermic) were treated with PUVA therapy. The psoriasis area and severity index (PASI) was used for evaluation. The average pretreatment PASI score was 14.6 (range 7.4-35.4) in chronic plaque psoriasis and 39.9 (22.3-52.2) in psoriatic erythrod...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
1998-01-01
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| Series: | Indian Journal of Dermatology |
| Online Access: | http://www.e-ijd.org/article.asp?issn=0019-5154;year=1998;volume=43;issue=3;spage=105;epage=107;aulast=Chavan;type=0 |
| _version_ | 1811240981655191552 |
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| author | Chavan Rajeshree G Joshi Rajiv Khopkar Uday S Phadke Vaishali A Wadhwa S.L |
| author_facet | Chavan Rajeshree G Joshi Rajiv Khopkar Uday S Phadke Vaishali A Wadhwa S.L |
| author_sort | Chavan Rajeshree G |
| collection | DOAJ |
| description | Forty live psoriatics (40 chronic plaque, 5 stable erythrodermic) were treated with PUVA therapy. The psoriasis area and severity index (PASI) was used for evaluation. The average pretreatment PASI score was 14.6 (range 7.4-35.4) in chronic plaque psoriasis and 39.9 (22.3-52.2) in psoriatic erythroderma. Patients were given oral 8-methoxypsoralen (0.6mg/kg), thrice a week with initial UVA exposure of 3 joulrd/cm2 and increments of 1 joulrd/cm2 every week till complete clearance or up to 12 weeks whichever was earlier. After clearing, patients were put on maintenance therapy. The average response at the end of 8 weeks was 84.5% reduction in PASI score in chronic plaque and 86.5% in erythroderma. Patients received a cumulative dose of 186 and 165 joules/cm2 respectively. Based on the time required for clearance, patients could be divided into rapid responders (4 weeks, 14 cases), average responders (8 weeks, 21 cases), slow responders (12 weeks, 5 cases) and non-responders (5 cases). One patient of chronic plaque type developed pustular psoriasis. No other serious side effect was observed. Hence, systemic photochemotherapy is effective in inducing long-lasting remissions in plaque and even stable erythrodermic psoriasis. More than 70% cases were maintained in remission at 6 months, 58% at 1 year and 32% at 2 years. |
| first_indexed | 2024-04-12T13:28:55Z |
| format | Article |
| id | doaj.art-1582a06cfab0458e801fd63168c4744e |
| institution | Directory Open Access Journal |
| issn | 0019-5154 1998-3611 |
| language | English |
| last_indexed | 2024-04-12T13:28:55Z |
| publishDate | 1998-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dermatology |
| spelling | doaj.art-1582a06cfab0458e801fd63168c4744e2022-12-22T03:31:13ZengWolters Kluwer Medknow PublicationsIndian Journal of Dermatology0019-51541998-36111998-01-01433105107Photochemotherapy For Widespread PsoriasisChavan Rajeshree GJoshi RajivKhopkar Uday SPhadke Vaishali AWadhwa S.LForty live psoriatics (40 chronic plaque, 5 stable erythrodermic) were treated with PUVA therapy. The psoriasis area and severity index (PASI) was used for evaluation. The average pretreatment PASI score was 14.6 (range 7.4-35.4) in chronic plaque psoriasis and 39.9 (22.3-52.2) in psoriatic erythroderma. Patients were given oral 8-methoxypsoralen (0.6mg/kg), thrice a week with initial UVA exposure of 3 joulrd/cm2 and increments of 1 joulrd/cm2 every week till complete clearance or up to 12 weeks whichever was earlier. After clearing, patients were put on maintenance therapy. The average response at the end of 8 weeks was 84.5% reduction in PASI score in chronic plaque and 86.5% in erythroderma. Patients received a cumulative dose of 186 and 165 joules/cm2 respectively. Based on the time required for clearance, patients could be divided into rapid responders (4 weeks, 14 cases), average responders (8 weeks, 21 cases), slow responders (12 weeks, 5 cases) and non-responders (5 cases). One patient of chronic plaque type developed pustular psoriasis. No other serious side effect was observed. Hence, systemic photochemotherapy is effective in inducing long-lasting remissions in plaque and even stable erythrodermic psoriasis. More than 70% cases were maintained in remission at 6 months, 58% at 1 year and 32% at 2 years.http://www.e-ijd.org/article.asp?issn=0019-5154;year=1998;volume=43;issue=3;spage=105;epage=107;aulast=Chavan;type=0 |
| spellingShingle | Chavan Rajeshree G Joshi Rajiv Khopkar Uday S Phadke Vaishali A Wadhwa S.L Photochemotherapy For Widespread Psoriasis Indian Journal of Dermatology |
| title | Photochemotherapy For Widespread Psoriasis |
| title_full | Photochemotherapy For Widespread Psoriasis |
| title_fullStr | Photochemotherapy For Widespread Psoriasis |
| title_full_unstemmed | Photochemotherapy For Widespread Psoriasis |
| title_short | Photochemotherapy For Widespread Psoriasis |
| title_sort | photochemotherapy for widespread psoriasis |
| url | http://www.e-ijd.org/article.asp?issn=0019-5154;year=1998;volume=43;issue=3;spage=105;epage=107;aulast=Chavan;type=0 |
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