From one to all: self-assembled theranostic nanoparticles for tumor-targeted imaging and programmed photoactive therapy
Abstract Background In recent years, multifunctional theranostic nanoparticles have been fabricated by integrating imaging and therapeutic moieties into one single nano-formulations. However, Complexity of production and safety issues limits their further application. Results Herein, we demonstrated...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-02-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12951-019-0450-x |
| _version_ | 1798038823645478912 |
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| author | Xianlei Li Xuan Wang Caiyan Zhao Leihou Shao Jianqing Lu Yujia Tong Long Chen Xinyue Cui Huiling Sun Junxing Liu Mingjun Li Xiongwei Deng Yan Wu |
| author_facet | Xianlei Li Xuan Wang Caiyan Zhao Leihou Shao Jianqing Lu Yujia Tong Long Chen Xinyue Cui Huiling Sun Junxing Liu Mingjun Li Xiongwei Deng Yan Wu |
| author_sort | Xianlei Li |
| collection | DOAJ |
| description | Abstract Background In recent years, multifunctional theranostic nanoparticles have been fabricated by integrating imaging and therapeutic moieties into one single nano-formulations. However, Complexity of production and safety issues limits their further application. Results Herein, we demonstrated self-assembled nanoparticles with single structure as a “from one to all” theranostic platform for tumor-targeted dual-modal imaging and programmed photoactive therapy (PPAT). The nanoparticles were successfully developed through self-assembling of hyaluronic acid (HA)-cystamine-cholesterol (HSC) conjugate, in which IR780 was simultaneously incorporated (HSCI NPs). Due to the proper hydrodynamic size and intrinsic targeting ability of HA, the HSCI NPs could accumulate at the tumor site effectively after systemic administration. In the presence of incorporated IR780, in vivo biodistribution and accumulation behaviors of HSCI NPs could be monitored by photoacoustic imaging. After cellular uptake, the HSCI NPs would disintegrate resulting from cystamine reacting with over-expressed GSH. The released IR780 would induce fluorescence “turn-on” conversion, which could be used to image tumor sites effectively. Upon treatment with 808 nm laser irradiation, PPAT could be achieved in which generated reactive oxygen species (ROS) would produce photodynamic therapy (PDT), and subsequently the raised temperature would be beneficial to tumor photothermal therapy (PTT). Conclusion The self-assembled HSCI NPs could act as “from one to all” theranostic platform for high treatment efficiency via PPAT pattern, which could also real-time monitor NPs accumulation by targeted and dual-modal imaging in a non-invasive way. |
| first_indexed | 2024-04-11T21:45:37Z |
| format | Article |
| id | doaj.art-1583db0d25c24c52ae5950e093e8d528 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-11T21:45:37Z |
| publishDate | 2019-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-1583db0d25c24c52ae5950e093e8d5282022-12-22T04:01:26ZengBMCJournal of Nanobiotechnology1477-31552019-02-0117111210.1186/s12951-019-0450-xFrom one to all: self-assembled theranostic nanoparticles for tumor-targeted imaging and programmed photoactive therapyXianlei Li0Xuan Wang1Caiyan Zhao2Leihou Shao3Jianqing Lu4Yujia Tong5Long Chen6Xinyue Cui7Huiling Sun8Junxing Liu9Mingjun Li10Xiongwei Deng11Yan Wu12CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and TechnologyCAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and TechnologyCAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and TechnologyCAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and TechnologyCAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and TechnologyCAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and TechnologyCAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and TechnologyCAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and TechnologyCAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and TechnologyThe First Affiliated Hospital of Jiamusi UniversityThe First Affiliated Hospital of Jiamusi UniversityCAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and TechnologyCAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and TechnologyAbstract Background In recent years, multifunctional theranostic nanoparticles have been fabricated by integrating imaging and therapeutic moieties into one single nano-formulations. However, Complexity of production and safety issues limits their further application. Results Herein, we demonstrated self-assembled nanoparticles with single structure as a “from one to all” theranostic platform for tumor-targeted dual-modal imaging and programmed photoactive therapy (PPAT). The nanoparticles were successfully developed through self-assembling of hyaluronic acid (HA)-cystamine-cholesterol (HSC) conjugate, in which IR780 was simultaneously incorporated (HSCI NPs). Due to the proper hydrodynamic size and intrinsic targeting ability of HA, the HSCI NPs could accumulate at the tumor site effectively after systemic administration. In the presence of incorporated IR780, in vivo biodistribution and accumulation behaviors of HSCI NPs could be monitored by photoacoustic imaging. After cellular uptake, the HSCI NPs would disintegrate resulting from cystamine reacting with over-expressed GSH. The released IR780 would induce fluorescence “turn-on” conversion, which could be used to image tumor sites effectively. Upon treatment with 808 nm laser irradiation, PPAT could be achieved in which generated reactive oxygen species (ROS) would produce photodynamic therapy (PDT), and subsequently the raised temperature would be beneficial to tumor photothermal therapy (PTT). Conclusion The self-assembled HSCI NPs could act as “from one to all” theranostic platform for high treatment efficiency via PPAT pattern, which could also real-time monitor NPs accumulation by targeted and dual-modal imaging in a non-invasive way.http://link.springer.com/article/10.1186/s12951-019-0450-xFrom one to allSelf-assemblingTheranostic nanoparticlesTargeted imagingProgrammed photoactive therapy |
| spellingShingle | Xianlei Li Xuan Wang Caiyan Zhao Leihou Shao Jianqing Lu Yujia Tong Long Chen Xinyue Cui Huiling Sun Junxing Liu Mingjun Li Xiongwei Deng Yan Wu From one to all: self-assembled theranostic nanoparticles for tumor-targeted imaging and programmed photoactive therapy Journal of Nanobiotechnology From one to all Self-assembling Theranostic nanoparticles Targeted imaging Programmed photoactive therapy |
| title | From one to all: self-assembled theranostic nanoparticles for tumor-targeted imaging and programmed photoactive therapy |
| title_full | From one to all: self-assembled theranostic nanoparticles for tumor-targeted imaging and programmed photoactive therapy |
| title_fullStr | From one to all: self-assembled theranostic nanoparticles for tumor-targeted imaging and programmed photoactive therapy |
| title_full_unstemmed | From one to all: self-assembled theranostic nanoparticles for tumor-targeted imaging and programmed photoactive therapy |
| title_short | From one to all: self-assembled theranostic nanoparticles for tumor-targeted imaging and programmed photoactive therapy |
| title_sort | from one to all self assembled theranostic nanoparticles for tumor targeted imaging and programmed photoactive therapy |
| topic | From one to all Self-assembling Theranostic nanoparticles Targeted imaging Programmed photoactive therapy |
| url | http://link.springer.com/article/10.1186/s12951-019-0450-x |
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