Suppressive Effect of Tetrahydrobiopterin on L-β-( 3,4-Dihydroxyphenyl) alanine-Induced Cytotoxicity in PC-12 Cells

Suppressive Effect of Tetrahydrobiopterin on L-β-( 3,4-Dihydroxyphenyl) alanine-Induced Cytotoxicity in PC-12 Cells

We examined the inhibitory effect of tetrahydrobiopterin (BPH4) on L-β-(3,4-dihydroxyphenyl)alanine (DOPA)-induced cytotoxicity in PC-12 cells. First in vitro inhibitory efficacy of BPH4 on lipid peroxidation induced by Fe3+-DOPA complex was confirmed by using PC-liposomes. Fe3+-DOPA complex at 50 μ...

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Bibliographic Details
Main Authors: Kojima Shuji, Kugenuma Hiroshi, Oyobe Sayaka, lizuka Hiroyuki, Ikekita Masahiko
Format: Article
Language:English
Published: De Gruyter 1997-01-01
Series:Pteridines
Subjects:
tetrahydrobiopterin
dopa
cytotoxicity
pc-12 cells
Online Access:https://doi.org/10.1515/pteridines.1997.8.1.10

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