The Continuing Value of Ultrastructural Observation in Central Nervous System Neoplasms in Children
Central nervous system (CNS) neoplasms are the second most common childhood malignancy after leukemia and the most common solid organ neoplasm in children. Diagnostic dilemmas with small specimens from CNS neoplasms are often the result of multifactorial etiologies such as frozen or fixation artifac...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Korean Society of Pathologists & the Korean Society for Cytopathology
2015-11-01
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| Series: | Journal of Pathology and Translational Medicine |
| Subjects: | |
| Online Access: | http://www.jpatholtm.org/upload/pdf/jptm-2015-09-19.pdf |
| _version_ | 1818961064228814848 |
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| author | Na Rae Kim Sung-Hye Park |
| author_facet | Na Rae Kim Sung-Hye Park |
| author_sort | Na Rae Kim |
| collection | DOAJ |
| description | Central nervous system (CNS) neoplasms are the second most common childhood malignancy after leukemia and the most common solid organ neoplasm in children. Diagnostic dilemmas with small specimens from CNS neoplasms are often the result of multifactorial etiologies such as frozen or fixation artifact, biopsy size, or lack of knowledge about rare or unfamiliar entities. Since the late 1950s, ultrastructural examination has been used in the diagnosis of CNS neoplasms, though it has largely been replaced by immunohistochemical and molecular cytogenetic studies. Nowadays, pathologic diagnosis of CNS neoplasms is achieved through intraoperative cytology, light microscopy, immunohistochemistry, and molecular cytogenetic results. However, the utility of electron microscopy (EM) in the final diagnosis of CNS neoplasms and investigation of its pathogenetic origin remains critical. Here, we reviewed the distinguishing ultrastructural features of pediatric CNS neoplasms and emphasize the continuing value of EM in the diagnosis of CNS neoplasms. |
| first_indexed | 2024-12-20T12:07:29Z |
| format | Article |
| id | doaj.art-1586f2ab028841308246c0ec407ab456 |
| institution | Directory Open Access Journal |
| issn | 2383-7837 2383-7845 |
| language | English |
| last_indexed | 2024-12-20T12:07:29Z |
| publishDate | 2015-11-01 |
| publisher | Korean Society of Pathologists & the Korean Society for Cytopathology |
| record_format | Article |
| series | Journal of Pathology and Translational Medicine |
| spelling | doaj.art-1586f2ab028841308246c0ec407ab4562022-12-21T19:41:20ZengKorean Society of Pathologists & the Korean Society for CytopathologyJournal of Pathology and Translational Medicine2383-78372383-78452015-11-0149642743710.4132/jptm.2015.09.1916559The Continuing Value of Ultrastructural Observation in Central Nervous System Neoplasms in ChildrenNa Rae KimSung-Hye Park0 Department of Pathology, Seoul National University College of Medicine, Seoul, KoreaCentral nervous system (CNS) neoplasms are the second most common childhood malignancy after leukemia and the most common solid organ neoplasm in children. Diagnostic dilemmas with small specimens from CNS neoplasms are often the result of multifactorial etiologies such as frozen or fixation artifact, biopsy size, or lack of knowledge about rare or unfamiliar entities. Since the late 1950s, ultrastructural examination has been used in the diagnosis of CNS neoplasms, though it has largely been replaced by immunohistochemical and molecular cytogenetic studies. Nowadays, pathologic diagnosis of CNS neoplasms is achieved through intraoperative cytology, light microscopy, immunohistochemistry, and molecular cytogenetic results. However, the utility of electron microscopy (EM) in the final diagnosis of CNS neoplasms and investigation of its pathogenetic origin remains critical. Here, we reviewed the distinguishing ultrastructural features of pediatric CNS neoplasms and emphasize the continuing value of EM in the diagnosis of CNS neoplasms.http://www.jpatholtm.org/upload/pdf/jptm-2015-09-19.pdfMicroscopy, electronCentral nervous systemNeoplasmsChildhood |
| spellingShingle | Na Rae Kim Sung-Hye Park The Continuing Value of Ultrastructural Observation in Central Nervous System Neoplasms in Children Journal of Pathology and Translational Medicine Microscopy, electron Central nervous system Neoplasms Childhood |
| title | The Continuing Value of Ultrastructural Observation in Central Nervous System Neoplasms in Children |
| title_full | The Continuing Value of Ultrastructural Observation in Central Nervous System Neoplasms in Children |
| title_fullStr | The Continuing Value of Ultrastructural Observation in Central Nervous System Neoplasms in Children |
| title_full_unstemmed | The Continuing Value of Ultrastructural Observation in Central Nervous System Neoplasms in Children |
| title_short | The Continuing Value of Ultrastructural Observation in Central Nervous System Neoplasms in Children |
| title_sort | continuing value of ultrastructural observation in central nervous system neoplasms in children |
| topic | Microscopy, electron Central nervous system Neoplasms Childhood |
| url | http://www.jpatholtm.org/upload/pdf/jptm-2015-09-19.pdf |
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