Polycystic Ovary Syndrome: Etiology, Current Management, and Future Therapeutics
Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder, typically characterized by anovulation, infertility, obesity, insulin resistance, and polycystic ovaries. Lifestyle or diet, environmental pollutants, genetics, gut dysbiosis, neuroendocrine alterations, and obesity are...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/4/1454 |
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| author | Samradhi Singh Namrata Pal Swasti Shubham Devojit Kumar Sarma Vinod Verma Francesco Marotta Manoj Kumar |
| author_facet | Samradhi Singh Namrata Pal Swasti Shubham Devojit Kumar Sarma Vinod Verma Francesco Marotta Manoj Kumar |
| author_sort | Samradhi Singh |
| collection | DOAJ |
| description | Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder, typically characterized by anovulation, infertility, obesity, insulin resistance, and polycystic ovaries. Lifestyle or diet, environmental pollutants, genetics, gut dysbiosis, neuroendocrine alterations, and obesity are among the risk factors that predispose females to PCOS. These factors might contribute to upsurging metabolic syndrome by causing hyperinsulinemia, oxidative stress, hyperandrogenism, impaired folliculogenesis, and irregular menstrual cycles. Dysbiosis of gut microbiota may play a pathogenic role in the development of PCOS. The restoration of gut microbiota by probiotics, prebiotics, or a fecal microbiota transplant (FMT) might serve as an innovative, efficient, and noninvasive way to prevent and mitigate PCOS. This review deliberates on the variety of risk factors potentially involved in the etiology, prevalence, and modulation of PCOS, in addition to plausible therapeutic interventions, including miRNA therapy and the eubiosis of gut microbiota, that may help treat and manage PCOS. |
| first_indexed | 2024-03-11T08:37:21Z |
| format | Article |
| id | doaj.art-15870a1a485c466c8c16f0a722268b70 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T08:37:21Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-15870a1a485c466c8c16f0a722268b702023-11-16T21:19:47ZengMDPI AGJournal of Clinical Medicine2077-03832023-02-01124145410.3390/jcm12041454Polycystic Ovary Syndrome: Etiology, Current Management, and Future TherapeuticsSamradhi Singh0Namrata Pal1Swasti Shubham2Devojit Kumar Sarma3Vinod Verma4Francesco Marotta5Manoj Kumar6ICMR—National Institute for Research in Environmental Health, Bhopal Bypass Road, Bhopal 462030, IndiaICMR—National Institute for Research in Environmental Health, Bhopal Bypass Road, Bhopal 462030, IndiaICMR—National Institute for Research in Environmental Health, Bhopal Bypass Road, Bhopal 462030, IndiaICMR—National Institute for Research in Environmental Health, Bhopal Bypass Road, Bhopal 462030, IndiaStem Cell Research Centre, Department of Hematology, Sanjay Gandhi Post-Graduate Institute of MedicalSciences, Lucknow 226014, IndiaReGenera R&D International for Aging Intervention, 20144 Milano, Lombardia, ItalyICMR—National Institute for Research in Environmental Health, Bhopal Bypass Road, Bhopal 462030, IndiaPolycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder, typically characterized by anovulation, infertility, obesity, insulin resistance, and polycystic ovaries. Lifestyle or diet, environmental pollutants, genetics, gut dysbiosis, neuroendocrine alterations, and obesity are among the risk factors that predispose females to PCOS. These factors might contribute to upsurging metabolic syndrome by causing hyperinsulinemia, oxidative stress, hyperandrogenism, impaired folliculogenesis, and irregular menstrual cycles. Dysbiosis of gut microbiota may play a pathogenic role in the development of PCOS. The restoration of gut microbiota by probiotics, prebiotics, or a fecal microbiota transplant (FMT) might serve as an innovative, efficient, and noninvasive way to prevent and mitigate PCOS. This review deliberates on the variety of risk factors potentially involved in the etiology, prevalence, and modulation of PCOS, in addition to plausible therapeutic interventions, including miRNA therapy and the eubiosis of gut microbiota, that may help treat and manage PCOS.https://www.mdpi.com/2077-0383/12/4/1454PCOSgut microbiomeprobioticsFMTgut dysbiosishyperinsulinemia |
| spellingShingle | Samradhi Singh Namrata Pal Swasti Shubham Devojit Kumar Sarma Vinod Verma Francesco Marotta Manoj Kumar Polycystic Ovary Syndrome: Etiology, Current Management, and Future Therapeutics Journal of Clinical Medicine PCOS gut microbiome probiotics FMT gut dysbiosis hyperinsulinemia |
| title | Polycystic Ovary Syndrome: Etiology, Current Management, and Future Therapeutics |
| title_full | Polycystic Ovary Syndrome: Etiology, Current Management, and Future Therapeutics |
| title_fullStr | Polycystic Ovary Syndrome: Etiology, Current Management, and Future Therapeutics |
| title_full_unstemmed | Polycystic Ovary Syndrome: Etiology, Current Management, and Future Therapeutics |
| title_short | Polycystic Ovary Syndrome: Etiology, Current Management, and Future Therapeutics |
| title_sort | polycystic ovary syndrome etiology current management and future therapeutics |
| topic | PCOS gut microbiome probiotics FMT gut dysbiosis hyperinsulinemia |
| url | https://www.mdpi.com/2077-0383/12/4/1454 |
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