[Translated article] Tirbanibulin: review of its novel mechanism of action and how it fits into the treatment of actinic keratosis
Actinic keratosis (AK), a skin condition characterized by the proliferation of atypical keratinocytes, can progress to squamous cell carcinoma. Existing treatments are effective but cause high rates of local skin reactions. Tirbanibulin, one of the treatments under development for AK, is a novel syn...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Actas Dermo-Sifiliográficas |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0001731022000217 |
| _version_ | 1798031179348180992 |
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| author | Y. Gilaberte M.T. Fernández-Figueras |
| author_facet | Y. Gilaberte M.T. Fernández-Figueras |
| author_sort | Y. Gilaberte |
| collection | DOAJ |
| description | Actinic keratosis (AK), a skin condition characterized by the proliferation of atypical keratinocytes, can progress to squamous cell carcinoma. Existing treatments are effective but cause high rates of local skin reactions. Tirbanibulin, one of the treatments under development for AK, is a novel synthetic drug with powerful in vitro and in vivo antiproliferative and antitumor effects. Its efficacy in this setting was recently demonstrated in 2 phase 3 clinical trials. We review tirbanibulin’s mechanism of action based on the current literature and several unpublished preclinical studies. We also review treatments available for AK and discuss how tirbanibulin, with its novel mechanism of action, fits into the therapeutic landscape. Resumen: La queratosis actínica (QA) es una afección cutánea caracterizada por la proliferación de queratinocitos mutados que pueden convertirse en carcinoma escamoso cutáneo. Las terapias disponibles, aunque efectivas, están asociadas con una alta frecuencia de reacciones cutáneas locales graves. Tirbanibulina, uno de los tratamientos para la QA actualmente en desarrollo, es un nuevo fármaco sintético de origen químico con potentes efectos antiproliferativos y antitumorales in vitro e in vivo con eficacia probada en el tratamiento de la QA, demostrada recientemente en dos ensayos clínicos de fase III. En la presente revisión, se muestra el mecanismo de acción de tirbanibulina en base a la literatura relevante y los resultados de varios estudios preclínicos no publicados. Además, se plantea el escenario actual en cuanto a los tratamientos disponibles y cómo el mecanismo de acción novedoso de tirbanibulina encaja en el tratamiento de la QA. |
| first_indexed | 2024-04-11T19:52:12Z |
| format | Article |
| id | doaj.art-158734b3851e44c68ee8659214adb2ba |
| institution | Directory Open Access Journal |
| issn | 0001-7310 |
| language | English |
| last_indexed | 2024-04-11T19:52:12Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Actas Dermo-Sifiliográficas |
| spelling | doaj.art-158734b3851e44c68ee8659214adb2ba2022-12-22T04:06:15ZengElsevierActas Dermo-Sifiliográficas0001-73102022-01-011131T58T66[Translated article] Tirbanibulin: review of its novel mechanism of action and how it fits into the treatment of actinic keratosisY. Gilaberte0M.T. Fernández-Figueras1Servicio de Dermatología, Hospital Universitario Miguel Servet, IIS Aragón, Zaragoza, Spain; Corresponding author.Servicio de Anatomía Patológica, Hospital Universitari General de Catalunya, Grupo Quirón Salud, Sant Cugat del Vallès, Barcelona, Spain; Universitat Internacional de Catalunya, Sant Cugat del Vallès, Barcelona, SpainActinic keratosis (AK), a skin condition characterized by the proliferation of atypical keratinocytes, can progress to squamous cell carcinoma. Existing treatments are effective but cause high rates of local skin reactions. Tirbanibulin, one of the treatments under development for AK, is a novel synthetic drug with powerful in vitro and in vivo antiproliferative and antitumor effects. Its efficacy in this setting was recently demonstrated in 2 phase 3 clinical trials. We review tirbanibulin’s mechanism of action based on the current literature and several unpublished preclinical studies. We also review treatments available for AK and discuss how tirbanibulin, with its novel mechanism of action, fits into the therapeutic landscape. Resumen: La queratosis actínica (QA) es una afección cutánea caracterizada por la proliferación de queratinocitos mutados que pueden convertirse en carcinoma escamoso cutáneo. Las terapias disponibles, aunque efectivas, están asociadas con una alta frecuencia de reacciones cutáneas locales graves. Tirbanibulina, uno de los tratamientos para la QA actualmente en desarrollo, es un nuevo fármaco sintético de origen químico con potentes efectos antiproliferativos y antitumorales in vitro e in vivo con eficacia probada en el tratamiento de la QA, demostrada recientemente en dos ensayos clínicos de fase III. En la presente revisión, se muestra el mecanismo de acción de tirbanibulina en base a la literatura relevante y los resultados de varios estudios preclínicos no publicados. Además, se plantea el escenario actual en cuanto a los tratamientos disponibles y cómo el mecanismo de acción novedoso de tirbanibulina encaja en el tratamiento de la QA.http://www.sciencedirect.com/science/article/pii/S0001731022000217TirbanibulinaQueratosis actínicaCarcinoma escamoso cutáneoMecanismo de acciónApoptosisAdherencia |
| spellingShingle | Y. Gilaberte M.T. Fernández-Figueras [Translated article] Tirbanibulin: review of its novel mechanism of action and how it fits into the treatment of actinic keratosis Actas Dermo-Sifiliográficas Tirbanibulina Queratosis actínica Carcinoma escamoso cutáneo Mecanismo de acción Apoptosis Adherencia |
| title | [Translated article] Tirbanibulin: review of its novel mechanism of action and how it fits into the treatment of actinic keratosis |
| title_full | [Translated article] Tirbanibulin: review of its novel mechanism of action and how it fits into the treatment of actinic keratosis |
| title_fullStr | [Translated article] Tirbanibulin: review of its novel mechanism of action and how it fits into the treatment of actinic keratosis |
| title_full_unstemmed | [Translated article] Tirbanibulin: review of its novel mechanism of action and how it fits into the treatment of actinic keratosis |
| title_short | [Translated article] Tirbanibulin: review of its novel mechanism of action and how it fits into the treatment of actinic keratosis |
| title_sort | translated article tirbanibulin review of its novel mechanism of action and how it fits into the treatment of actinic keratosis |
| topic | Tirbanibulina Queratosis actínica Carcinoma escamoso cutáneo Mecanismo de acción Apoptosis Adherencia |
| url | http://www.sciencedirect.com/science/article/pii/S0001731022000217 |
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