Brain insulin signaling and cognition
Poor cognitive ability is a consequence of a wide variety of neurobehavioral disorders and is a growing health problem, especially among the elderly and patients with diabetes. The precise underlying cause of this complication is not well-defined. However, recent studies have highlighted the possibl...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
2023-02-01
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| Series: | EXCLI Journal : Experimental and Clinical Sciences |
| Subjects: | |
| Online Access: | https://www.excli.de/index.php/excli/article/view/5841 |
| _version_ | 1797843487647858688 |
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| author | Habib Yaribeygi Mina Maleki Alexandra E. Butler Tannaz Jamialahamdi Amirhossein Sahebkar |
| author_facet | Habib Yaribeygi Mina Maleki Alexandra E. Butler Tannaz Jamialahamdi Amirhossein Sahebkar |
| author_sort | Habib Yaribeygi |
| collection | DOAJ |
| description | Poor cognitive ability is a consequence of a wide variety of neurobehavioral disorders and is a growing health problem, especially among the elderly and patients with diabetes. The precise underlying cause of this complication is not well-defined. However, recent studies have highlighted the possible role of insulin hormone signaling in brain tissue. Insulin is a metabolic peptide integral to whole body energy homeostasis; it does, however, have extrametabolic impacts, such as upon neuronal circuits. Therefore, it has been suggested that insulin signaling may modify cognitive ability by yet unknown pathways. In the current review, we discuss the cognitive role of brain insulin signaling and consider the possible links between brain insulin signaling and cognitive ability. |
| first_indexed | 2024-04-09T17:07:04Z |
| format | Article |
| id | doaj.art-15876505fb3a40f0bd4cfcb03639576f |
| institution | Directory Open Access Journal |
| issn | 1611-2156 |
| language | English |
| last_indexed | 2024-04-09T17:07:04Z |
| publishDate | 2023-02-01 |
| publisher | IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund |
| record_format | Article |
| series | EXCLI Journal : Experimental and Clinical Sciences |
| spelling | doaj.art-15876505fb3a40f0bd4cfcb03639576f2023-04-20T12:30:49ZengIfADo - Leibniz Research Centre for Working Environment and Human Factors, DortmundEXCLI Journal : Experimental and Clinical Sciences1611-21562023-02-012223724910.17179/excli2023-58415280Brain insulin signaling and cognitionHabib Yaribeygi0https://orcid.org/0000-0002-1706-6212Mina Maleki1https://orcid.org/0000-0003-4723-3058Alexandra E. Butler2https://orcid.org/0000-0002-5762-3917Tannaz Jamialahamdi3https://orcid.org/0000-0001-9521-3153Amirhossein Sahebkar4https://orcid.org/0000-0002-8656-1444Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran. E-mail: habib.yari@yahoo.comUrology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranResearch Department, Royal College of Surgeons in Ireland, Bahrain, PO Box 15503, Adliya, BahrainApplied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, IranApplied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. E-mail: amir_saheb2000@yahoo.comPoor cognitive ability is a consequence of a wide variety of neurobehavioral disorders and is a growing health problem, especially among the elderly and patients with diabetes. The precise underlying cause of this complication is not well-defined. However, recent studies have highlighted the possible role of insulin hormone signaling in brain tissue. Insulin is a metabolic peptide integral to whole body energy homeostasis; it does, however, have extrametabolic impacts, such as upon neuronal circuits. Therefore, it has been suggested that insulin signaling may modify cognitive ability by yet unknown pathways. In the current review, we discuss the cognitive role of brain insulin signaling and consider the possible links between brain insulin signaling and cognitive ability.https://www.excli.de/index.php/excli/article/view/5841diabetes mellitusbrain insulin signalingcognitionsenile plaquemitochondria |
| spellingShingle | Habib Yaribeygi Mina Maleki Alexandra E. Butler Tannaz Jamialahamdi Amirhossein Sahebkar Brain insulin signaling and cognition EXCLI Journal : Experimental and Clinical Sciences diabetes mellitus brain insulin signaling cognition senile plaque mitochondria |
| title | Brain insulin signaling and cognition |
| title_full | Brain insulin signaling and cognition |
| title_fullStr | Brain insulin signaling and cognition |
| title_full_unstemmed | Brain insulin signaling and cognition |
| title_short | Brain insulin signaling and cognition |
| title_sort | brain insulin signaling and cognition |
| topic | diabetes mellitus brain insulin signaling cognition senile plaque mitochondria |
| url | https://www.excli.de/index.php/excli/article/view/5841 |
| work_keys_str_mv | AT habibyaribeygi braininsulinsignalingandcognition AT minamaleki braininsulinsignalingandcognition AT alexandraebutler braininsulinsignalingandcognition AT tannazjamialahamdi braininsulinsignalingandcognition AT amirhosseinsahebkar braininsulinsignalingandcognition |