Mesenchymal Stem Cells Genetically Modified by Lentivirus-Express Soluble TRAIL and Interleukin-12 Inhibit Growth and Reduced Metastasis-Relate Changes in Lymphoma Mice Model

Mesenchymal Stem Cells Genetically Modified by Lentivirus-Express Soluble TRAIL and Interleukin-12 Inhibit Growth and Reduced Metastasis-Relate Changes in Lymphoma Mice Model

Background: Cancer treatment has many side effects; therefore, more efficient treatments are needed. Mesenchymal stem cells (MSC) have immunoregulatory properties, tumor site migration and can be genetically modified. Some proteins, such as soluble TRAIL (sTRAIL) and interleukin-12 (IL-12), have sho...

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Bibliographic Details
Main Authors: Adriana G. Quiroz-Reyes, Carlos A. Gonzalez-Villarreal, Alberto Y. Limon-Flores, Paulina Delgado-Gonzalez, Herminia G. Martinez-Rodriguez, Salvador L. Said-Fernandez, Adolfo Soto-Dominguez, Ana M. Rivas-Estilla, Jose F. Islas, Juan F. Molina-De la Garza, Elsa N. Garza-Treviño
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Biomedicines
Subjects:
mesenchymal stem cells 1
lymphoma 2
TNF-related apoptosis-inducing ligand 3
interleulin-12 4
sTRAIL 5
Online Access:https://www.mdpi.com/2227-9059/11/2/595

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