Loss of Ptpn11 (Shp2) drives satellite cells into quiescence

Loss of Ptpn11 (Shp2) drives satellite cells into quiescence

The equilibrium between proliferation and quiescence of myogenic progenitor and stem cells is tightly regulated to ensure appropriate skeletal muscle growth and repair. The non-receptor tyrosine phosphatase Ptpn11 (Shp2) is an important transducer of growth factor and cytokine signals. Here we combi...

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Bibliographic Details
Main Authors: Joscha Griger, Robin Schneider, Ines Lahmann, Verena Schöwel, Charles Keller, Simone Spuler, Marc Nazare, Carmen Birchmeier
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-05-01
Series:eLife
Subjects:
Shp2
Ptpn11
satellite cells
skeletal muscle repair
skeletal muscle growth
quiescence
Online Access:https://elifesciences.org/articles/21552

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