Bacterial meningitis in children with an abnormal craniocerebral structure
BackgroundWe studied the causative pathogens, clinical characteristics, and outcome of bacterial meningitis in children with an abnormal craniocerebral structure.MethodsA retrospective single-center study was conducted on children aged in the range of 29 days to 14 years by using data obtained from...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.997163/full |
| _version_ | 1797858995430490112 |
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| author | Jiali Pan Wei Xu Wenliang Song Tao Zhang |
| author_facet | Jiali Pan Wei Xu Wenliang Song Tao Zhang |
| author_sort | Jiali Pan |
| collection | DOAJ |
| description | BackgroundWe studied the causative pathogens, clinical characteristics, and outcome of bacterial meningitis in children with an abnormal craniocerebral structure.MethodsA retrospective single-center study was conducted on children aged in the range of 29 days to 14 years by using data obtained from the pediatric intensive care unit in Shengjing Hospital between January 2014 and August 2021. All children were diagnosed with bacterial meningitis. They were divided into complex and simple groups by taking into account the presence of an abnormal craniocerebral structure before they contracted bacterial meningitis. We collected data on demographics, clinical presentations, laboratory results, imaging studies, treatments, and outcomes.ResultsA total of 207 patients were included in the study (46 in the complex group and 161 in the simple group). Patients in the complex group had a lower mortality rate (6.5% vs. 11.2%, p < 0.05), positive blood culture (13.0% vs. 34.8%; p < 0.05), multiple organ dysfunction syndrome (0% vs. 9.3%; p < 0.05), and shock (2.2% vs. 9.3%; p = 0.11). These patients were more often detected with neurological sequelae (80.4% vs. 53.4%; p < 0.05), cerebrospinal fluid drainage (50% vs. 15.5%; p < 0.05), nosocomial infection (54.3% vs. 3.1%; p < 0.05), and multidrug-resistant bacteria (62.5% vs. 55.6%, p = 0.501). In patients in the simple group, infection was mostly confined to the nervous system.ConclusionBacterial meningitis patients with an abnormal craniocerebral structure had fewer bloodstream infections, lower mortality rates, and higher incidence rates of neurological sequelae. Pathogens were more likely to be nosocomial and multidrug-resistant bacteria. |
| first_indexed | 2024-04-09T21:22:21Z |
| format | Article |
| id | doaj.art-1589246095b444779ab623d1354c913f |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-09T21:22:21Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-1589246095b444779ab623d1354c913f2023-03-28T04:41:25ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602023-03-011110.3389/fped.2023.997163997163Bacterial meningitis in children with an abnormal craniocerebral structureJiali PanWei XuWenliang SongTao ZhangBackgroundWe studied the causative pathogens, clinical characteristics, and outcome of bacterial meningitis in children with an abnormal craniocerebral structure.MethodsA retrospective single-center study was conducted on children aged in the range of 29 days to 14 years by using data obtained from the pediatric intensive care unit in Shengjing Hospital between January 2014 and August 2021. All children were diagnosed with bacterial meningitis. They were divided into complex and simple groups by taking into account the presence of an abnormal craniocerebral structure before they contracted bacterial meningitis. We collected data on demographics, clinical presentations, laboratory results, imaging studies, treatments, and outcomes.ResultsA total of 207 patients were included in the study (46 in the complex group and 161 in the simple group). Patients in the complex group had a lower mortality rate (6.5% vs. 11.2%, p < 0.05), positive blood culture (13.0% vs. 34.8%; p < 0.05), multiple organ dysfunction syndrome (0% vs. 9.3%; p < 0.05), and shock (2.2% vs. 9.3%; p = 0.11). These patients were more often detected with neurological sequelae (80.4% vs. 53.4%; p < 0.05), cerebrospinal fluid drainage (50% vs. 15.5%; p < 0.05), nosocomial infection (54.3% vs. 3.1%; p < 0.05), and multidrug-resistant bacteria (62.5% vs. 55.6%, p = 0.501). In patients in the simple group, infection was mostly confined to the nervous system.ConclusionBacterial meningitis patients with an abnormal craniocerebral structure had fewer bloodstream infections, lower mortality rates, and higher incidence rates of neurological sequelae. Pathogens were more likely to be nosocomial and multidrug-resistant bacteria.https://www.frontiersin.org/articles/10.3389/fped.2023.997163/fullbacterial meningitisabnormal craniocerebral structurepediatric intensive care unitchildreninfection |
| spellingShingle | Jiali Pan Wei Xu Wenliang Song Tao Zhang Bacterial meningitis in children with an abnormal craniocerebral structure Frontiers in Pediatrics bacterial meningitis abnormal craniocerebral structure pediatric intensive care unit children infection |
| title | Bacterial meningitis in children with an abnormal craniocerebral structure |
| title_full | Bacterial meningitis in children with an abnormal craniocerebral structure |
| title_fullStr | Bacterial meningitis in children with an abnormal craniocerebral structure |
| title_full_unstemmed | Bacterial meningitis in children with an abnormal craniocerebral structure |
| title_short | Bacterial meningitis in children with an abnormal craniocerebral structure |
| title_sort | bacterial meningitis in children with an abnormal craniocerebral structure |
| topic | bacterial meningitis abnormal craniocerebral structure pediatric intensive care unit children infection |
| url | https://www.frontiersin.org/articles/10.3389/fped.2023.997163/full |
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