Antidepressants and the risk of psoriasis induction: A case–control study
Background: Psoriasis (PSO) is a common chronic autoimmune skin disease with a significant psycho-socio-economic burden. Some antidepressants (ADs) such as fluoxetine and bupropion can induce or exacerbate PSO. This study aimed to investigate the correlation between ADs history before PSO onset, and...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Advanced Biomedical Research |
| Subjects: | |
| Online Access: | http://www.advbiores.net/article.asp?issn=2277-9175;year=2023;volume=12;issue=1;spage=16;epage=16;aulast=Sadatmadani |
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| author | Seyedeh-Fatemeh Sadatmadani Amir Hossein Siadat Fariba Iraji Fereshteh Alsahebfosoul |
| author_facet | Seyedeh-Fatemeh Sadatmadani Amir Hossein Siadat Fariba Iraji Fereshteh Alsahebfosoul |
| author_sort | Seyedeh-Fatemeh Sadatmadani |
| collection | DOAJ |
| description | Background: Psoriasis (PSO) is a common chronic autoimmune skin disease with a significant psycho-socio-economic burden. Some antidepressants (ADs) such as fluoxetine and bupropion can induce or exacerbate PSO. This study aimed to investigate the correlation between ADs history before PSO onset, and the risk of PSO induction, in Isfahan province, Iran.
Materials and Methods: In this case–control study, 80 patients with PSO were selected by non-probability sampling method, and 80 healthy individuals were selected using simple random sampling. They were interviewed and medical information was recorded. Chi-square, Mann–Whitney, and Kruskal–Wallis tests for dichotomous or categorical data, and independent-sample t test for continuous data were used. Statistical significance was taken as P ≤ 0.05.
Results: In this case–control study, a total of 160 individuals, 80 participants in each group, were included. The mean age of the total samples was 44.8 ± 16 years. Forty-three percent of the individuals were women. PSO familial history in the cases was significantly higher than the control group (OR = 11.94, P = 0.001). It was revealed that use of ADs by patients before PSO induction, was greater than the controls (OR = 2.78, P = 0.058).
Conclusions: Past history of ADs in the cases before PSO onset, was higher than the controls, indicating a possible association between ADs and the risk of PSO induction. This study can be effective to pay more attention to the possible complications of ADs and PSO risk factors. Accurate knowledge of PSO risk factors will be useful for better management and morbidity reduction. |
| first_indexed | 2024-03-11T15:47:42Z |
| format | Article |
| id | doaj.art-1589ed5f3e654a04a2d4f62ee1662cd1 |
| institution | Directory Open Access Journal |
| issn | 2277-9175 |
| language | English |
| last_indexed | 2024-03-11T15:47:42Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Advanced Biomedical Research |
| spelling | doaj.art-1589ed5f3e654a04a2d4f62ee1662cd12023-10-26T05:43:15ZengWolters Kluwer Medknow PublicationsAdvanced Biomedical Research2277-91752023-01-01121161610.4103/abr.abr_88_21Antidepressants and the risk of psoriasis induction: A case–control studySeyedeh-Fatemeh SadatmadaniAmir Hossein SiadatFariba IrajiFereshteh AlsahebfosoulBackground: Psoriasis (PSO) is a common chronic autoimmune skin disease with a significant psycho-socio-economic burden. Some antidepressants (ADs) such as fluoxetine and bupropion can induce or exacerbate PSO. This study aimed to investigate the correlation between ADs history before PSO onset, and the risk of PSO induction, in Isfahan province, Iran. Materials and Methods: In this case–control study, 80 patients with PSO were selected by non-probability sampling method, and 80 healthy individuals were selected using simple random sampling. They were interviewed and medical information was recorded. Chi-square, Mann–Whitney, and Kruskal–Wallis tests for dichotomous or categorical data, and independent-sample t test for continuous data were used. Statistical significance was taken as P ≤ 0.05. Results: In this case–control study, a total of 160 individuals, 80 participants in each group, were included. The mean age of the total samples was 44.8 ± 16 years. Forty-three percent of the individuals were women. PSO familial history in the cases was significantly higher than the control group (OR = 11.94, P = 0.001). It was revealed that use of ADs by patients before PSO induction, was greater than the controls (OR = 2.78, P = 0.058). Conclusions: Past history of ADs in the cases before PSO onset, was higher than the controls, indicating a possible association between ADs and the risk of PSO induction. This study can be effective to pay more attention to the possible complications of ADs and PSO risk factors. Accurate knowledge of PSO risk factors will be useful for better management and morbidity reduction.http://www.advbiores.net/article.asp?issn=2277-9175;year=2023;volume=12;issue=1;spage=16;epage=16;aulast=Sadatmadaniantidepressantsautoimmune dermatologic diseasedepressionpsoriasis |
| spellingShingle | Seyedeh-Fatemeh Sadatmadani Amir Hossein Siadat Fariba Iraji Fereshteh Alsahebfosoul Antidepressants and the risk of psoriasis induction: A case–control study Advanced Biomedical Research antidepressants autoimmune dermatologic disease depression psoriasis |
| title | Antidepressants and the risk of psoriasis induction: A case–control study |
| title_full | Antidepressants and the risk of psoriasis induction: A case–control study |
| title_fullStr | Antidepressants and the risk of psoriasis induction: A case–control study |
| title_full_unstemmed | Antidepressants and the risk of psoriasis induction: A case–control study |
| title_short | Antidepressants and the risk of psoriasis induction: A case–control study |
| title_sort | antidepressants and the risk of psoriasis induction a case control study |
| topic | antidepressants autoimmune dermatologic disease depression psoriasis |
| url | http://www.advbiores.net/article.asp?issn=2277-9175;year=2023;volume=12;issue=1;spage=16;epage=16;aulast=Sadatmadani |
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