Short term exposure to low amounts of airway irritants in a swine confinement building and inflammatory markers in blood and exhaled air
Introduction and objective. Swine confinement buildings are known to contain large concentrations of airway irritants, and a number of studies have shown acute inflammatory effects in previously unexposed subjects when introduced to the environment in such buildings. However, studies comparing diffe...
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| Format: | Article |
| Language: | English |
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Institute of Rural Health
2014-09-01
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| Series: | Annals of Agricultural and Environmental Medicine |
| Subjects: | |
| Online Access: | http://journals.indexcopernicus.com/fulltxt.php?ICID=1120587 |
| _version_ | 1819178894122549248 |
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| author | Bjørn Lyngen Morten Buhagen Torgunn Qvenild Kristin Svendsen Ellen Tufvesson Bjørn Hilt |
| author_facet | Bjørn Lyngen Morten Buhagen Torgunn Qvenild Kristin Svendsen Ellen Tufvesson Bjørn Hilt |
| author_sort | Bjørn Lyngen |
| collection | DOAJ |
| description | Introduction and objective. Swine confinement buildings are known to contain large concentrations of airway irritants, and a number of studies have shown acute inflammatory effects in previously unexposed subjects when introduced to the environment in such buildings. However, studies comparing different methods of assessing such reactions are lacking, and it is not known if a measurable response could be found at lower exposure rates. The purpose of this study was to investigate exposure levels in a Norwegian swine confinement building, the airway response to such exposure, and to compare invasive and non-invasive methods of response measurement.
Materials and method. Twelve medical students who were previously unexposed to swine dust stayed in a swine confinement building in Norway for 4 hours, and underwent measurements before and after the start of exposure. The same measurements were also performed beforehand, on the same weekday without exposure, in such a manner that the subjects were their own controls.
Results. The exposure assessment showed considerably lower concentrations of organic dust and endotoxin than earlier studies. However, small, but significant increases in markers of airway inflammation, were found.
Conclusions. Airway response can be measured after lower exposure to airborne irritants in swine confinement buildings than previously known. Further research is needed to assess whether this finding can be utilized for preventive purposes. |
| first_indexed | 2024-12-22T21:49:48Z |
| format | Article |
| id | doaj.art-158a26ec2a004c4b899875b409bdd13f |
| institution | Directory Open Access Journal |
| issn | 1232-1966 1898-2263 |
| language | English |
| last_indexed | 2024-12-22T21:49:48Z |
| publishDate | 2014-09-01 |
| publisher | Institute of Rural Health |
| record_format | Article |
| series | Annals of Agricultural and Environmental Medicine |
| spelling | doaj.art-158a26ec2a004c4b899875b409bdd13f2022-12-21T18:11:24ZengInstitute of Rural HealthAnnals of Agricultural and Environmental Medicine1232-19661898-22632014-09-0121875194479484Short term exposure to low amounts of airway irritants in a swine confinement building and inflammatory markers in blood and exhaled airBjørn Lyngen0Morten Buhagen1Torgunn Qvenild2Kristin Svendsen3Ellen Tufvesson4Bjørn Hilt5Department of Occupational Medicine, St. Olavs University Hospital, Trondheim, Norway Department of Industrial Economics and Technology Management, Norwegian University of Science and Technology, Trondheim, NorwayDepartment of Industrial Economics and Technology Management, Norwegian University of Science and Technology, Trondheim, NorwayDepartment of Industrial Economics and Technology Management, Norwegian University of Science and Technology, Trondheim, NorwayRespiratory Medicine and Allergology, Department of Clinical Sciences in Lund, Lund University, Lund, SwedenDepartment of Occupational Medicine, St. Olavs University Hospital, Trondheim, Norway; Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway Introduction and objective. Swine confinement buildings are known to contain large concentrations of airway irritants, and a number of studies have shown acute inflammatory effects in previously unexposed subjects when introduced to the environment in such buildings. However, studies comparing different methods of assessing such reactions are lacking, and it is not known if a measurable response could be found at lower exposure rates. The purpose of this study was to investigate exposure levels in a Norwegian swine confinement building, the airway response to such exposure, and to compare invasive and non-invasive methods of response measurement. Materials and method. Twelve medical students who were previously unexposed to swine dust stayed in a swine confinement building in Norway for 4 hours, and underwent measurements before and after the start of exposure. The same measurements were also performed beforehand, on the same weekday without exposure, in such a manner that the subjects were their own controls. Results. The exposure assessment showed considerably lower concentrations of organic dust and endotoxin than earlier studies. However, small, but significant increases in markers of airway inflammation, were found. Conclusions. Airway response can be measured after lower exposure to airborne irritants in swine confinement buildings than previously known. Further research is needed to assess whether this finding can be utilized for preventive purposes.http://journals.indexcopernicus.com/fulltxt.php?ICID=1120587Exposure;endotoxin;organic dust;Swine;Agriculture |
| spellingShingle | Bjørn Lyngen Morten Buhagen Torgunn Qvenild Kristin Svendsen Ellen Tufvesson Bjørn Hilt Short term exposure to low amounts of airway irritants in a swine confinement building and inflammatory markers in blood and exhaled air Annals of Agricultural and Environmental Medicine Exposure;endotoxin;organic dust;Swine;Agriculture |
| title | Short term exposure to low amounts of airway irritants in a swine confinement building and inflammatory markers in blood and exhaled air |
| title_full | Short term exposure to low amounts of airway irritants in a swine confinement building and inflammatory markers in blood and exhaled air |
| title_fullStr | Short term exposure to low amounts of airway irritants in a swine confinement building and inflammatory markers in blood and exhaled air |
| title_full_unstemmed | Short term exposure to low amounts of airway irritants in a swine confinement building and inflammatory markers in blood and exhaled air |
| title_short | Short term exposure to low amounts of airway irritants in a swine confinement building and inflammatory markers in blood and exhaled air |
| title_sort | short term exposure to low amounts of airway irritants in a swine confinement building and inflammatory markers in blood and exhaled air |
| topic | Exposure;endotoxin;organic dust;Swine;Agriculture |
| url | http://journals.indexcopernicus.com/fulltxt.php?ICID=1120587 |
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