TIGAR Attenuates High Glucose-Induced Neuronal Apoptosis via an Autophagy Pathway

TIGAR Attenuates High Glucose-Induced Neuronal Apoptosis via an Autophagy Pathway

Hyperglycemia-induced neuronal apoptosis is one of the important reasons for diabetic neuropathy. Long-time exposure to high glucose accelerates many aberrant glucose metabolic pathways and eventually leads to neuronal injury. However, the underlying mechanisms of metabolic alterations remain unknow...

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Bibliographic Details
Main Authors: Wenjuan Zhou, Yuan Yao, Jinxing Li, Dong Wu, Man Zhao, Zongting Yan, Aimei Pang, Liang Kong
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
hyperglycemia
TIGAR
neuronal apoptosis
autophagy
NOS1
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00193/full

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