The Potential of Non-Provitamin A Carotenoids for the Prevention and Treatment of Non-Alcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease (NAFLD) is an obesity-associated spectrum of comorbidities defined by the presence of metabolic dysfunction, oxidative stress, inflammation, and fibrosis in the liver. If left untreated, NAFLD can progress to cirrhosis, liver failure, or hepatocellular carcinoma. NA...
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| Format: | Article |
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MDPI AG
2016-11-01
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| Series: | Biology |
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| Online Access: | http://www.mdpi.com/2079-7737/5/4/42 |
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| author | Ana Gabriela Murillo Diana M. DiMarco Maria Luz Fernandez |
| author_facet | Ana Gabriela Murillo Diana M. DiMarco Maria Luz Fernandez |
| author_sort | Ana Gabriela Murillo |
| collection | DOAJ |
| description | Non-alcoholic fatty liver disease (NAFLD) is an obesity-associated spectrum of comorbidities defined by the presence of metabolic dysfunction, oxidative stress, inflammation, and fibrosis in the liver. If left untreated, NAFLD can progress to cirrhosis, liver failure, or hepatocellular carcinoma. NAFLD is recognized as the most common liver disease in the United States, affecting around 30% of the population. Identification of dietary components capable of reducing or preventing NAFLD is therefore essential to battle this condition. Dietary carotenoids including astaxanthin, lycopene, lutein, and zeaxanthin have been demonstrated to be potent antioxidants as well as to exhibit anti-inflammatory effects. Many studies report the protective effect(s) of these carotenoids against different conditions such as atherosclerosis, diabetic complications, age-related macular degeneration, and liver diseases. In this review, we will focus on the effects of these carotenoids in the prevention or reduction of NAFLD as seen in epidemiological observations and clinical trials, as well as the suggested mechanism of action derived from animal and cell studies. |
| first_indexed | 2024-03-12T07:13:49Z |
| format | Article |
| id | doaj.art-158aa3733e6240768a502113fdd23cb2 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-12T07:13:49Z |
| publishDate | 2016-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-158aa3733e6240768a502113fdd23cb22023-09-02T22:55:24ZengMDPI AGBiology2079-77372016-11-01544210.3390/biology5040042biology5040042The Potential of Non-Provitamin A Carotenoids for the Prevention and Treatment of Non-Alcoholic Fatty Liver DiseaseAna Gabriela Murillo0Diana M. DiMarco1Maria Luz Fernandez2Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USADepartment of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USADepartment of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USANon-alcoholic fatty liver disease (NAFLD) is an obesity-associated spectrum of comorbidities defined by the presence of metabolic dysfunction, oxidative stress, inflammation, and fibrosis in the liver. If left untreated, NAFLD can progress to cirrhosis, liver failure, or hepatocellular carcinoma. NAFLD is recognized as the most common liver disease in the United States, affecting around 30% of the population. Identification of dietary components capable of reducing or preventing NAFLD is therefore essential to battle this condition. Dietary carotenoids including astaxanthin, lycopene, lutein, and zeaxanthin have been demonstrated to be potent antioxidants as well as to exhibit anti-inflammatory effects. Many studies report the protective effect(s) of these carotenoids against different conditions such as atherosclerosis, diabetic complications, age-related macular degeneration, and liver diseases. In this review, we will focus on the effects of these carotenoids in the prevention or reduction of NAFLD as seen in epidemiological observations and clinical trials, as well as the suggested mechanism of action derived from animal and cell studies.http://www.mdpi.com/2079-7737/5/4/42non-alcoholic fatty liver disease (NAFLD)carotenoidslycopeneastaxanthinluteinzeaxanthinhepatic steatosis |
| spellingShingle | Ana Gabriela Murillo Diana M. DiMarco Maria Luz Fernandez The Potential of Non-Provitamin A Carotenoids for the Prevention and Treatment of Non-Alcoholic Fatty Liver Disease Biology non-alcoholic fatty liver disease (NAFLD) carotenoids lycopene astaxanthin lutein zeaxanthin hepatic steatosis |
| title | The Potential of Non-Provitamin A Carotenoids for the Prevention and Treatment of Non-Alcoholic Fatty Liver Disease |
| title_full | The Potential of Non-Provitamin A Carotenoids for the Prevention and Treatment of Non-Alcoholic Fatty Liver Disease |
| title_fullStr | The Potential of Non-Provitamin A Carotenoids for the Prevention and Treatment of Non-Alcoholic Fatty Liver Disease |
| title_full_unstemmed | The Potential of Non-Provitamin A Carotenoids for the Prevention and Treatment of Non-Alcoholic Fatty Liver Disease |
| title_short | The Potential of Non-Provitamin A Carotenoids for the Prevention and Treatment of Non-Alcoholic Fatty Liver Disease |
| title_sort | potential of non provitamin a carotenoids for the prevention and treatment of non alcoholic fatty liver disease |
| topic | non-alcoholic fatty liver disease (NAFLD) carotenoids lycopene astaxanthin lutein zeaxanthin hepatic steatosis |
| url | http://www.mdpi.com/2079-7737/5/4/42 |
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