Systemic side-effects of topical ophthalmic drops in a 17-year old boy candidate for deep viterectomy: a case report
Background: Drugs applied topically to the eye may be absorbed systemically to a substantial degree, with the potential to cause serious systemic side-effects. Children may be particularly vulnerable to systemic effects of topically applied agents as topical doses are often not weight-adjusted. Case...
| Main Authors: | , |
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| Format: | Article |
| Language: | fas |
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Tehran University of Medical Sciences
2012-07-01
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| Series: | Tehran University Medical Journal |
| Subjects: | |
| Online Access: | http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-129&slc_lang=en&sid=1 |
| _version_ | 1818422439626932224 |
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| author | Zahedi H Maleki A |
| author_facet | Zahedi H Maleki A |
| author_sort | Zahedi H |
| collection | DOAJ |
| description | Background: Drugs applied topically to the eye may be absorbed systemically to a substantial degree, with the potential to cause serious systemic side-effects. Children may be particularly vulnerable to systemic effects of topically applied agents as topical doses are often not weight-adjusted.
Case presentation: This article describes a case of serious systemic side-effect by the use of topical phenylephrine, tetracaine, tropicamide and atropine in a 17-year old boy candidate for deep viterectomy in Farabi Hospital in 1389. Following application of the aforesaid eye drops, the patient developed hypertension and subsequent loss of conciseness.
Conclusion: Several types of eye drops and their repeated use can lead to their systemic absorption and medical complications due to overdose. Strategies to minimize systemic absorption should be applied, including use of low concentrations of ophthalmic drugs, administration of one type of the drug, use of microdrops and punctal occlusion to minimize absorption via the nasolacrimal duct. While administering ophthalmic drops, one should take these precautions to minimize the systemic effects of the drugs to prevent subsequent complications. |
| first_indexed | 2024-12-14T13:26:17Z |
| format | Article |
| id | doaj.art-158aa6bad9d041b18ddb8477fbee119a |
| institution | Directory Open Access Journal |
| issn | 1683-1764 1735-7322 |
| language | fas |
| last_indexed | 2024-12-14T13:26:17Z |
| publishDate | 2012-07-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Tehran University Medical Journal |
| spelling | doaj.art-158aa6bad9d041b18ddb8477fbee119a2022-12-21T22:59:49ZfasTehran University of Medical SciencesTehran University Medical Journal1683-17641735-73222012-07-01704270274Systemic side-effects of topical ophthalmic drops in a 17-year old boy candidate for deep viterectomy: a case reportZahedi H0Maleki A1 Background: Drugs applied topically to the eye may be absorbed systemically to a substantial degree, with the potential to cause serious systemic side-effects. Children may be particularly vulnerable to systemic effects of topically applied agents as topical doses are often not weight-adjusted. Case presentation: This article describes a case of serious systemic side-effect by the use of topical phenylephrine, tetracaine, tropicamide and atropine in a 17-year old boy candidate for deep viterectomy in Farabi Hospital in 1389. Following application of the aforesaid eye drops, the patient developed hypertension and subsequent loss of conciseness. Conclusion: Several types of eye drops and their repeated use can lead to their systemic absorption and medical complications due to overdose. Strategies to minimize systemic absorption should be applied, including use of low concentrations of ophthalmic drugs, administration of one type of the drug, use of microdrops and punctal occlusion to minimize absorption via the nasolacrimal duct. While administering ophthalmic drops, one should take these precautions to minimize the systemic effects of the drugs to prevent subsequent complications.http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-129&slc_lang=en&sid=1atropinephenylephrinesystemic side-effectstetracainetopical ophthalmic medicationstropicamide |
| spellingShingle | Zahedi H Maleki A Systemic side-effects of topical ophthalmic drops in a 17-year old boy candidate for deep viterectomy: a case report Tehran University Medical Journal atropine phenylephrine systemic side-effects tetracaine topical ophthalmic medications tropicamide |
| title | Systemic side-effects of topical ophthalmic drops in a 17-year old boy candidate for deep viterectomy: a case report |
| title_full | Systemic side-effects of topical ophthalmic drops in a 17-year old boy candidate for deep viterectomy: a case report |
| title_fullStr | Systemic side-effects of topical ophthalmic drops in a 17-year old boy candidate for deep viterectomy: a case report |
| title_full_unstemmed | Systemic side-effects of topical ophthalmic drops in a 17-year old boy candidate for deep viterectomy: a case report |
| title_short | Systemic side-effects of topical ophthalmic drops in a 17-year old boy candidate for deep viterectomy: a case report |
| title_sort | systemic side effects of topical ophthalmic drops in a 17 year old boy candidate for deep viterectomy a case report |
| topic | atropine phenylephrine systemic side-effects tetracaine topical ophthalmic medications tropicamide |
| url | http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-129&slc_lang=en&sid=1 |
| work_keys_str_mv | AT zahedih systemicsideeffectsoftopicalophthalmicdropsina17yearoldboycandidatefordeepviterectomyacasereport AT malekia systemicsideeffectsoftopicalophthalmicdropsina17yearoldboycandidatefordeepviterectomyacasereport |