Handgrip strength and all‐cause dementia incidence and mortality: findings from the UK Biobank prospective cohort study
Abstract Background This study aimed to investigate the associations of grip strength with incidence and mortality from dementia and whether these associations differ by sociodemographic and lifestyle factors. Methods A total of 466 788 participants of the UK Biobank (median age 56.5 years, 54.5% wo...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-06-01
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| Series: | Journal of Cachexia, Sarcopenia and Muscle |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jcsm.12857 |
| _version_ | 1827070675178749952 |
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| author | Irene Esteban‐Cornejo Frederick K. Ho Fanny Petermann‐Rocha Donald M. Lyall David Martinez‐Gomez Verónica Cabanas‐Sánchez Francisco B. Ortega Charles H. Hillman Jason M.R. Gill Terence J. Quinn Naveed Sattar Jill P. Pell Stuart R. Gray Carlos Celis‐Morales |
| author_facet | Irene Esteban‐Cornejo Frederick K. Ho Fanny Petermann‐Rocha Donald M. Lyall David Martinez‐Gomez Verónica Cabanas‐Sánchez Francisco B. Ortega Charles H. Hillman Jason M.R. Gill Terence J. Quinn Naveed Sattar Jill P. Pell Stuart R. Gray Carlos Celis‐Morales |
| author_sort | Irene Esteban‐Cornejo |
| collection | DOAJ |
| description | Abstract Background This study aimed to investigate the associations of grip strength with incidence and mortality from dementia and whether these associations differ by sociodemographic and lifestyle factors. Methods A total of 466 788 participants of the UK Biobank (median age 56.5 years, 54.5% women). The outcome was all‐cause dementia incidence and mortality and the exposure was grip strength. Grip strength was assessed using a Jamar J00105 hydraulic hand dynamometer. Results Excluding the first 2 years of follow‐up (landmark analysis), mean follow‐up was 9.1 years (inter‐quartile range: 8.3; 9.7) for incidence and 9.3 (inter‐quartile range: 8.7; 10.0) for mortality. During this time, 4087 participants developed dementia, and 1309 died from it. Lower grip strength was associated with a higher risk of dementia incidence and mortality independent of major confounding factors (P < 0.001). Individuals in the lowest quintile of grip strength had 72% [95% confidence interval (CI): 1.55; 1.92] higher incident dementia risk and 87% [95% CI: 1.55; 2.26] higher risk of dementia mortality compared with those in the highest quintile. Our PAF analyses indicate that 30.1% of dementia cases and 32.3% of dementia deaths are attributable to having low grip strength. The association between grip strength and dementia outcomes did not differ by lifestyle or sociodemographic factors. Conclusions Lower grip strength was associated with a higher risk of all‐cause dementia incidence and mortality, independently of important confounding factors. |
| first_indexed | 2024-04-12T13:14:53Z |
| format | Article |
| id | doaj.art-158bab48fbb74105bc436c46b75db791 |
| institution | Directory Open Access Journal |
| issn | 2190-5991 2190-6009 |
| language | English |
| last_indexed | 2025-03-20T00:26:17Z |
| publishDate | 2022-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Cachexia, Sarcopenia and Muscle |
| spelling | doaj.art-158bab48fbb74105bc436c46b75db7912024-10-10T03:50:48ZengWileyJournal of Cachexia, Sarcopenia and Muscle2190-59912190-60092022-06-011331514152510.1002/jcsm.12857Handgrip strength and all‐cause dementia incidence and mortality: findings from the UK Biobank prospective cohort studyIrene Esteban‐Cornejo0Frederick K. Ho1Fanny Petermann‐Rocha2Donald M. Lyall3David Martinez‐Gomez4Verónica Cabanas‐Sánchez5Francisco B. Ortega6Charles H. Hillman7Jason M.R. Gill8Terence J. Quinn9Naveed Sattar10Jill P. Pell11Stuart R. Gray12Carlos Celis‐Morales13PROFITH “PROmoting FITness and Health through physical activity” Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical Education and Sports, Faculty of Sport Sciences University of Granada Granada SpainInstitute of Health and Wellbeing University of Glasgow Glasgow UKInstitute of Health and Wellbeing University of Glasgow Glasgow UKInstitute of Health and Wellbeing University of Glasgow Glasgow UKDepartment of Preventive Medicine and Public Health Autonomous University of Madrid/IdiPaz, CIBER of Epidemiology and Public Health (CIBERESP) Madrid SpainIMDEA Food Institute, CEI UAM + CSIC Madrid SpainPROFITH “PROmoting FITness and Health through physical activity” Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical Education and Sports, Faculty of Sport Sciences University of Granada Granada SpainDepartment of Psychology Northeastern University Boston MA USABHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences University of Glasgow Glasgow UKBHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences University of Glasgow Glasgow UKBHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences University of Glasgow Glasgow UKInstitute of Health and Wellbeing University of Glasgow Glasgow UKBHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences University of Glasgow Glasgow UKBHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences University of Glasgow Glasgow UKAbstract Background This study aimed to investigate the associations of grip strength with incidence and mortality from dementia and whether these associations differ by sociodemographic and lifestyle factors. Methods A total of 466 788 participants of the UK Biobank (median age 56.5 years, 54.5% women). The outcome was all‐cause dementia incidence and mortality and the exposure was grip strength. Grip strength was assessed using a Jamar J00105 hydraulic hand dynamometer. Results Excluding the first 2 years of follow‐up (landmark analysis), mean follow‐up was 9.1 years (inter‐quartile range: 8.3; 9.7) for incidence and 9.3 (inter‐quartile range: 8.7; 10.0) for mortality. During this time, 4087 participants developed dementia, and 1309 died from it. Lower grip strength was associated with a higher risk of dementia incidence and mortality independent of major confounding factors (P < 0.001). Individuals in the lowest quintile of grip strength had 72% [95% confidence interval (CI): 1.55; 1.92] higher incident dementia risk and 87% [95% CI: 1.55; 2.26] higher risk of dementia mortality compared with those in the highest quintile. Our PAF analyses indicate that 30.1% of dementia cases and 32.3% of dementia deaths are attributable to having low grip strength. The association between grip strength and dementia outcomes did not differ by lifestyle or sociodemographic factors. Conclusions Lower grip strength was associated with a higher risk of all‐cause dementia incidence and mortality, independently of important confounding factors.https://doi.org/10.1002/jcsm.12857AlzheimerVascular dementiaMuscular strengthPreventionAdultsMortality |
| spellingShingle | Irene Esteban‐Cornejo Frederick K. Ho Fanny Petermann‐Rocha Donald M. Lyall David Martinez‐Gomez Verónica Cabanas‐Sánchez Francisco B. Ortega Charles H. Hillman Jason M.R. Gill Terence J. Quinn Naveed Sattar Jill P. Pell Stuart R. Gray Carlos Celis‐Morales Handgrip strength and all‐cause dementia incidence and mortality: findings from the UK Biobank prospective cohort study Journal of Cachexia, Sarcopenia and Muscle Alzheimer Vascular dementia Muscular strength Prevention Adults Mortality |
| title | Handgrip strength and all‐cause dementia incidence and mortality: findings from the UK Biobank prospective cohort study |
| title_full | Handgrip strength and all‐cause dementia incidence and mortality: findings from the UK Biobank prospective cohort study |
| title_fullStr | Handgrip strength and all‐cause dementia incidence and mortality: findings from the UK Biobank prospective cohort study |
| title_full_unstemmed | Handgrip strength and all‐cause dementia incidence and mortality: findings from the UK Biobank prospective cohort study |
| title_short | Handgrip strength and all‐cause dementia incidence and mortality: findings from the UK Biobank prospective cohort study |
| title_sort | handgrip strength and all cause dementia incidence and mortality findings from the uk biobank prospective cohort study |
| topic | Alzheimer Vascular dementia Muscular strength Prevention Adults Mortality |
| url | https://doi.org/10.1002/jcsm.12857 |
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