Clinical Manifestations and Outcomes of West Nile Virus Infection
Since the emergence of West Nile virus (WNV) in North America in 1999, understanding of the clinical features, spectrum of illness and eventual functional outcomes of human illness has increased tremendously. Most human infections with WNV remain clinically silent. Among those persons developing sym...
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-02-01
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| Series: | Viruses |
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| Online Access: | http://www.mdpi.com/1999-4915/6/2/606 |
| _version_ | 1818578286839595008 |
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| author | James J. Sejvar |
| author_facet | James J. Sejvar |
| author_sort | James J. Sejvar |
| collection | DOAJ |
| description | Since the emergence of West Nile virus (WNV) in North America in 1999, understanding of the clinical features, spectrum of illness and eventual functional outcomes of human illness has increased tremendously. Most human infections with WNV remain clinically silent. Among those persons developing symptomatic illness, most develop a self-limited febrile illness. More severe illness with WNV (West Nile neuroinvasive disease, WNND) is manifested as meningitis, encephalitis or an acute anterior (polio) myelitis. These manifestations are generally more prevalent in older persons or those with immunosuppression. In the future, a more thorough understanding of the long-term physical, cognitive and functional outcomes of persons recovering from WNV illness will be important in understanding the overall illness burden. |
| first_indexed | 2024-12-16T06:43:24Z |
| format | Article |
| id | doaj.art-158ec00126024e3c88d35ad04b3d0351 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-16T06:43:24Z |
| publishDate | 2014-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-158ec00126024e3c88d35ad04b3d03512022-12-21T22:40:38ZengMDPI AGViruses1999-49152014-02-016260662310.3390/v6020606v6020606Clinical Manifestations and Outcomes of West Nile Virus InfectionJames J. Sejvar0National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USASince the emergence of West Nile virus (WNV) in North America in 1999, understanding of the clinical features, spectrum of illness and eventual functional outcomes of human illness has increased tremendously. Most human infections with WNV remain clinically silent. Among those persons developing symptomatic illness, most develop a self-limited febrile illness. More severe illness with WNV (West Nile neuroinvasive disease, WNND) is manifested as meningitis, encephalitis or an acute anterior (polio) myelitis. These manifestations are generally more prevalent in older persons or those with immunosuppression. In the future, a more thorough understanding of the long-term physical, cognitive and functional outcomes of persons recovering from WNV illness will be important in understanding the overall illness burden.http://www.mdpi.com/1999-4915/6/2/606West Nile virusmeningitisencephalitispoliomyelitisoutcomes |
| spellingShingle | James J. Sejvar Clinical Manifestations and Outcomes of West Nile Virus Infection Viruses West Nile virus meningitis encephalitis poliomyelitis outcomes |
| title | Clinical Manifestations and Outcomes of West Nile Virus Infection |
| title_full | Clinical Manifestations and Outcomes of West Nile Virus Infection |
| title_fullStr | Clinical Manifestations and Outcomes of West Nile Virus Infection |
| title_full_unstemmed | Clinical Manifestations and Outcomes of West Nile Virus Infection |
| title_short | Clinical Manifestations and Outcomes of West Nile Virus Infection |
| title_sort | clinical manifestations and outcomes of west nile virus infection |
| topic | West Nile virus meningitis encephalitis poliomyelitis outcomes |
| url | http://www.mdpi.com/1999-4915/6/2/606 |
| work_keys_str_mv | AT jamesjsejvar clinicalmanifestationsandoutcomesofwestnilevirusinfection |