Effect of sclerostin inactivation in a mouse model of severe dominant osteogenesis imperfecta
Abstract Osteogenesis imperfecta (OI) is a rare bone disease that is associated with fractures and low bone mass. Sclerostin inhibition is being evaluated as a potential approach to increase bone mass in OI. We had previously found that in Col1a1 Jrt/+ mice, a model of severe OI, treatment with an a...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-03-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-023-32221-3 |