Gene signature reveals decreased SOX10-dependent transcripts in malignant cells from immune checkpoint inhibitor-resistant cutaneous melanomas

Gene signature reveals decreased SOX10-dependent transcripts in malignant cells from immune checkpoint inhibitor-resistant cutaneous melanomas

Summary: Evidence is mounting for cross-resistance between immune checkpoint and targeted kinase inhibitor therapies in cutaneous melanoma patients. Since the loss of the transcription factor, SOX10, causes tolerance to MAPK pathway inhibitors, we used bioinformatic techniques to determine if reduce...

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Bibliographic Details
Main Authors: Timothy J. Purwin, Signe Caksa, Ahmet Sacan, Claudia Capparelli, Andrew E. Aplin
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:iScience
Subjects:
Classification Description
Molecular network
Cancer systems biology
Omics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223015493

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