Managing a Pregnancy in the Presence of the Rare Blood Group Antibody PP1Pk

Managing a Pregnancy in the Presence of the Rare Blood Group Antibody PP1Pk

Pregnant women with p phenotype, who lack antigens P, P1, and Pk, spontaneously form anti-PP1Pk antibodies whose primary target is the placenta. The risk of miscarriage in these women is 50%?70% and reaches 87% in the second trimester. The therapies aim to reduce the titer of antibodies early in pre...

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Bibliographic Details
Main Authors: Alexandra Bonmat?-Santan?, Roberto C?spedes L?pez, Jehimy Jean Alvarez Saltos, Jordi Calabia Mart?nez, Cristina Noboa Paez, Jordi Piedra S?nchez, Natalia Visa Figueredo, Anna Maroto Gonz?lez
Format: Article
Language:English
Published: Mary Ann Liebert 2024-04-01
Series:Women's Health Reports
Subjects:
plasmapheresis
anti-PP1Pk
autologous blood donation
miscarriage
p phenotype
Online Access:https://www.liebertpub.com/doi/full/10.1089/WHR.2023.0120
Description
Summary:Pregnant women with p phenotype, who lack antigens P, P1, and Pk, spontaneously form anti-PP1Pk antibodies whose primary target is the placenta. The risk of miscarriage in these women is 50%?70% and reaches 87% in the second trimester. The therapies aim to reduce the titer of antibodies early in pregnancy. They also have risk of hemolytic transfusion reaction, with very few compatible red blood cell donors in the world. In this study, we present a case of successful pregnancy managed with autologous blood donations and plasmapheresis.
ISSN:2688-4844

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