Cyclic stress-strain behavior of polymeric nonwoven structures for the use as artificial leaflet material for transcatheter heart valve prostheses
Xenogenic leaflet material, bovine and porcine pericardium, is widely used for the fabrication of surgically implanted and transcatheter heart valve prostheses. As a biological material, long term durability of pericardium is limited due to calcification, degeneration and homogeneity. Therefore, pol...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2017-09-01
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| Series: | Current Directions in Biomedical Engineering |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/cdbme-2017-0149 |
| _version_ | 1797848687882272768 |
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| author | Arbeiter Daniela Brandt-Wunderlich Christoph Siewert Stefan Kohse Stefanie Pfensig Sylvia Schmitz Klaus-Peter Grabow Niels |
| author_facet | Arbeiter Daniela Brandt-Wunderlich Christoph Siewert Stefan Kohse Stefanie Pfensig Sylvia Schmitz Klaus-Peter Grabow Niels |
| author_sort | Arbeiter Daniela |
| collection | DOAJ |
| description | Xenogenic leaflet material, bovine and porcine pericardium, is widely used for the fabrication of surgically implanted and transcatheter heart valve prostheses. As a biological material, long term durability of pericardium is limited due to calcification, degeneration and homogeneity. Therefore, polymeric materials represent a promising approach for a next generation of artificial heart valve leaflets with improved durability. Within the current study we analyzed the mechanical performance of polymeric structures based on elastomeric materials. Polymeric cast films were prepared and nonwovens were manufactured in an electrospinning process. Analysis of cyclic stress-strain behavior was performed, using a universal testing machine. The uniaxial cyclic tensile experiments of the elastomeric samples yielded a non-linear elastic response due to viscoelastic behavior with hysteresis. Equilibrium of stress-strain curves was found after a specific number of cycles, for cast films and nonwovens, respectively. In conclusion, preconditioning was found obligatory for the evaluation of the mechanical performance of polymeric materials for the use as artificial leaflet material for heart valve prostheses. |
| first_indexed | 2024-04-09T18:32:40Z |
| format | Article |
| id | doaj.art-1592c960e7e6407a86e9b92de2ed2250 |
| institution | Directory Open Access Journal |
| issn | 2364-5504 |
| language | English |
| last_indexed | 2024-04-09T18:32:40Z |
| publishDate | 2017-09-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Current Directions in Biomedical Engineering |
| spelling | doaj.art-1592c960e7e6407a86e9b92de2ed22502023-04-11T17:07:14ZengDe GruyterCurrent Directions in Biomedical Engineering2364-55042017-09-013270370610.1515/cdbme-2017-0149cdbme-2017-0149Cyclic stress-strain behavior of polymeric nonwoven structures for the use as artificial leaflet material for transcatheter heart valve prosthesesArbeiter Daniela0Brandt-Wunderlich Christoph1Siewert Stefan2Kohse Stefanie3Pfensig Sylvia4Schmitz Klaus-Peter5Grabow Niels6Institute for Biomedical Engineering, Rostock University Medical Center, Friedrich-Barnewitz-Str. 4, 18119 Rostock-Warnemünde, GermanyInstitute for ImplantTechnology and Biomaterials e.V., Friedrich-Barnewitz-Str. 4, 18119 Rostock-Warnemünde, GermanyInstitute for ImplantTechnology and Biomaterials e.V., Friedrich-Barnewitz-Str. 4, 18119 Rostock-Warnemünde, GermanyInstitute for Biomedical Engineering, Rostock University Medical Center, Friedrich-Barnewitz-Str. 4, 18119 Rostock-Warnemünde, GermanyInstitute for ImplantTechnology and Biomaterials e.V., Friedrich-Barnewitz-Str. 4, 18119 Rostock-Warnemünde, GermanyInstitute for Biomedical Engineering, Rostock University Medical Center, Friedrich-Barnewitz-Str. 4, 18119 Rostock-Warnemünde, GermanyInstitute for Biomedical Engineering, Rostock University Medical Center, Friedrich-Barnewitz-Str. 4, 18119 Rostock-Warnemünde, GermanyXenogenic leaflet material, bovine and porcine pericardium, is widely used for the fabrication of surgically implanted and transcatheter heart valve prostheses. As a biological material, long term durability of pericardium is limited due to calcification, degeneration and homogeneity. Therefore, polymeric materials represent a promising approach for a next generation of artificial heart valve leaflets with improved durability. Within the current study we analyzed the mechanical performance of polymeric structures based on elastomeric materials. Polymeric cast films were prepared and nonwovens were manufactured in an electrospinning process. Analysis of cyclic stress-strain behavior was performed, using a universal testing machine. The uniaxial cyclic tensile experiments of the elastomeric samples yielded a non-linear elastic response due to viscoelastic behavior with hysteresis. Equilibrium of stress-strain curves was found after a specific number of cycles, for cast films and nonwovens, respectively. In conclusion, preconditioning was found obligatory for the evaluation of the mechanical performance of polymeric materials for the use as artificial leaflet material for heart valve prostheses.https://doi.org/10.1515/cdbme-2017-0149cyclic tensile teststhermoplastic silicone-based polyurethanetranscatheter heart valve prostheses |
| spellingShingle | Arbeiter Daniela Brandt-Wunderlich Christoph Siewert Stefan Kohse Stefanie Pfensig Sylvia Schmitz Klaus-Peter Grabow Niels Cyclic stress-strain behavior of polymeric nonwoven structures for the use as artificial leaflet material for transcatheter heart valve prostheses Current Directions in Biomedical Engineering cyclic tensile tests thermoplastic silicone-based polyurethane transcatheter heart valve prostheses |
| title | Cyclic stress-strain behavior of polymeric nonwoven structures for the use as artificial leaflet material for transcatheter heart valve prostheses |
| title_full | Cyclic stress-strain behavior of polymeric nonwoven structures for the use as artificial leaflet material for transcatheter heart valve prostheses |
| title_fullStr | Cyclic stress-strain behavior of polymeric nonwoven structures for the use as artificial leaflet material for transcatheter heart valve prostheses |
| title_full_unstemmed | Cyclic stress-strain behavior of polymeric nonwoven structures for the use as artificial leaflet material for transcatheter heart valve prostheses |
| title_short | Cyclic stress-strain behavior of polymeric nonwoven structures for the use as artificial leaflet material for transcatheter heart valve prostheses |
| title_sort | cyclic stress strain behavior of polymeric nonwoven structures for the use as artificial leaflet material for transcatheter heart valve prostheses |
| topic | cyclic tensile tests thermoplastic silicone-based polyurethane transcatheter heart valve prostheses |
| url | https://doi.org/10.1515/cdbme-2017-0149 |
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