Atomistic MD simulation reveals the mechanism by which CETP penetrates into HDL enabling lipid transfer from HDL to CETP

Atomistic MD simulation reveals the mechanism by which CETP penetrates into HDL enabling lipid transfer from HDL to CETP

Inhibition of cholesterol ester transfer protein (CETP), a protein mediating transfer of neutral lipids between lipoproteins, has been proposed as a means to elevate atheroprotective HDL subpopulations and thereby reduce atherosclerosis. However, off-target and adverse effects of the inhibition have...

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Bibliographic Details
Main Authors: Geraldine Cilpa-Karhu, Matti Jauhiainen, Marja-Liisa Riekkola
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Journal of Lipid Research
Subjects:
atherosclerosis
cholesterol/trafficking
estrogen
high density lipoprotein/metabolism
lipid transfer protein
lipoproteins
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520356431

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