A simple role for BDNF in learning and memory?
Since its discovery almost three decades ago, the secreted neurotrophin brain-derived neurotrophic factor (BDNF) has been firmly implicated in the differentiation and survival of neurons of the CNS. More recently, BDNF has also emerged as an important regulator of synaptogenesis and synaptic plastic...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2010-02-01
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| Series: | Frontiers in Molecular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/neuro.02.001.2010/full |
| _version_ | 1811316870262816768 |
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| author | Carla Cunha Carla Cunha Riccardo Brambilla Kerrie L Thomas |
| author_facet | Carla Cunha Carla Cunha Riccardo Brambilla Kerrie L Thomas |
| author_sort | Carla Cunha |
| collection | DOAJ |
| description | Since its discovery almost three decades ago, the secreted neurotrophin brain-derived neurotrophic factor (BDNF) has been firmly implicated in the differentiation and survival of neurons of the CNS. More recently, BDNF has also emerged as an important regulator of synaptogenesis and synaptic plasticity mechanisms underlying learning and memory in the adult CNS. In this review we will discuss our knowledge about the multiple intracellular signalling pathways activated by BDNF, and the role of this neurotrophin in long-term synaptic plasticity and memory formation as well as in synaptogenesis. We will show that maturation of BDNF, its cellular localisation and its ability to regulate both excitatory and inhibitory synapses in the CNS may result in conflicting alterations in synaptic plasticity and memory formation. Lack of a precise knowledge about the mechanisms by which BDNF influences higher cognitive functions and complex behaviours may constitute a severe limitation in the possibility to devise BDNF-based therapeutics for human disorders of the CNS. |
| first_indexed | 2024-04-13T11:56:48Z |
| format | Article |
| id | doaj.art-1595f4c329074788b8cab09174c9f704 |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-04-13T11:56:48Z |
| publishDate | 2010-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-1595f4c329074788b8cab09174c9f7042022-12-22T02:47:53ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992010-02-01310.3389/neuro.02.001.2010865A simple role for BDNF in learning and memory?Carla Cunha0Carla Cunha1Riccardo Brambilla2Kerrie L Thomas3Center for Nanomedicine and Tissue Engineering,Center for Nanomedicine and Tissue Engineering ,A.O. Ospedale Niguarda Ca' GrandaUniversity of Milano-BicoccaSan Raffaele Scientific Institute and UniversityCardiff UniversitySince its discovery almost three decades ago, the secreted neurotrophin brain-derived neurotrophic factor (BDNF) has been firmly implicated in the differentiation and survival of neurons of the CNS. More recently, BDNF has also emerged as an important regulator of synaptogenesis and synaptic plasticity mechanisms underlying learning and memory in the adult CNS. In this review we will discuss our knowledge about the multiple intracellular signalling pathways activated by BDNF, and the role of this neurotrophin in long-term synaptic plasticity and memory formation as well as in synaptogenesis. We will show that maturation of BDNF, its cellular localisation and its ability to regulate both excitatory and inhibitory synapses in the CNS may result in conflicting alterations in synaptic plasticity and memory formation. Lack of a precise knowledge about the mechanisms by which BDNF influences higher cognitive functions and complex behaviours may constitute a severe limitation in the possibility to devise BDNF-based therapeutics for human disorders of the CNS.http://journal.frontiersin.org/Journal/10.3389/neuro.02.001.2010/fullBDNFsynaptic plasticitylearning and memorybehaviourcell signallingsynaptogenesis |
| spellingShingle | Carla Cunha Carla Cunha Riccardo Brambilla Kerrie L Thomas A simple role for BDNF in learning and memory? Frontiers in Molecular Neuroscience BDNF synaptic plasticity learning and memory behaviour cell signalling synaptogenesis |
| title | A simple role for BDNF in learning and memory? |
| title_full | A simple role for BDNF in learning and memory? |
| title_fullStr | A simple role for BDNF in learning and memory? |
| title_full_unstemmed | A simple role for BDNF in learning and memory? |
| title_short | A simple role for BDNF in learning and memory? |
| title_sort | simple role for bdnf in learning and memory |
| topic | BDNF synaptic plasticity learning and memory behaviour cell signalling synaptogenesis |
| url | http://journal.frontiersin.org/Journal/10.3389/neuro.02.001.2010/full |
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