Prediction of exacerbation chronic bronchopulmonary diseases in children with influenza
The objective: To develop a method for predicting exacerbation of chronic illness in children with asthma and cystic fibrosis, patients with influenza, based on the study of the dynamics of cytokines. Materials and methods: Were examined 52 patients with bronchial asthma and 45 children with cystic...
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| Format: | Article |
| Language: | Russian |
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Journal Infectology
2015-04-01
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| Series: | Журнал инфектологии |
| Subjects: | |
| Online Access: | https://journal.niidi.ru/jofin/article/view/374 |
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| author | O. I. Afanaseva E. G. Golovachyova V. S. Afanaseva V. F. Suhoveckaja E. A. Nikitina E. G. Koroleva А. V. Orlov L. B. Vayner L. A. Zhelenina |
| author_facet | O. I. Afanaseva E. G. Golovachyova V. S. Afanaseva V. F. Suhoveckaja E. A. Nikitina E. G. Koroleva А. V. Orlov L. B. Vayner L. A. Zhelenina |
| author_sort | O. I. Afanaseva |
| collection | DOAJ |
| description | The objective: To develop a method for predicting exacerbation of chronic illness in children with asthma and cystic fibrosis, patients with influenza, based on the study of the dynamics of cytokines. Materials and methods: Were examined 52 patients with bronchial asthma and 45 children with cystic fibrosis at the age from 1 year to 12 years, located in infectious pulmonary Department at the planned treatment of underlying pathology, in which influenza was in-hospital infection. Control group observations included 40 patients with the flu, without concomitant pulmonary disease. The etiology of viral infection was established by detection of viral RNA in nasopharyngeal swabs by PCR. Among the influenza viruses were identified influenza АH1N1, АH3N2, influenza B, and in 2009–2010 the predominant antigen was the pandemic influenza virus АH1N1pdm09. Determination of the concentration of serum interleukins IL-1β, IL-4, IL-8, IL-10, ТNF-α, IFN-γ was performed in the 1st and 3rd day of hospitalization cytokines by the solid-phase immune-enzyme assay. Analysis of the results performed using statistical package SPSS 17.0 EN for Windows. Results: The flu caused the aggravation associated bronchopulmonary pathology in 2/3 of children, as MV patients, and patients with BA (65,4%-66,7%, respectively). With an increase of the ratio of IL-4 / IFN-γ and IL-10/IFN-γ, at least 5-6 times, influenza can be considered a trigger of exacerbation of chronic bronchopulmonary pathologies that require amplification of the therapy of bronchial asthma and of сystic fibrosis. The growth of prognostic coefficients in 2-3 times allows using for treatment of influenza in these patients only antiviral agents. Conclusion: The study has shown a method for predicting exacerbation of bronchial asthma and cystic fibrosis in children at an early stage of influenza by calculating the ratio of IL-4/IFN-γ and IL-10/IFN-γ in children aged from 1 year to 12 years. |
| first_indexed | 2024-03-12T09:59:58Z |
| format | Article |
| id | doaj.art-159618c564dc4ae9995cea39dac99a14 |
| institution | Directory Open Access Journal |
| issn | 2072-6732 |
| language | Russian |
| last_indexed | 2024-03-12T09:59:58Z |
| publishDate | 2015-04-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj.art-159618c564dc4ae9995cea39dac99a142023-09-02T11:46:03ZrusJournal InfectologyЖурнал инфектологии2072-67322015-04-0171535810.22625/2072-6732-2015-7-1-53-58388Prediction of exacerbation chronic bronchopulmonary diseases in children with influenzaO. I. Afanaseva0E. G. Golovachyova1V. S. Afanaseva2V. F. Suhoveckaja3E. A. Nikitina4E. G. Koroleva5А. V. Orlov6L. B. Vayner7L. A. Zhelenina8Научно-исследовательский институт гриппа, Санкт-Петербург, РоссияНаучно-исследовательский институт гриппа, Санкт-Петербург, РоссияНаучно-исследовательский институт гриппа, Санкт-Петербург, РоссияНаучно-исследовательский институт гриппа, Санкт-Петербург, РоссияНаучно-исследовательский институт гриппа, Санкт-Петербург, РоссияНаучно-исследовательский институт гриппа, Санкт-Петербург, РоссияДетская городская больница Святой Ольги, Санкт-Петербург, РоссияДетская городская больница Святой Ольги, Санкт-Петербург, РоссияСанкт-Петербургский государственный педиатрический медицинский университет, Санкт-Петербург, РоссияThe objective: To develop a method for predicting exacerbation of chronic illness in children with asthma and cystic fibrosis, patients with influenza, based on the study of the dynamics of cytokines. Materials and methods: Were examined 52 patients with bronchial asthma and 45 children with cystic fibrosis at the age from 1 year to 12 years, located in infectious pulmonary Department at the planned treatment of underlying pathology, in which influenza was in-hospital infection. Control group observations included 40 patients with the flu, without concomitant pulmonary disease. The etiology of viral infection was established by detection of viral RNA in nasopharyngeal swabs by PCR. Among the influenza viruses were identified influenza АH1N1, АH3N2, influenza B, and in 2009–2010 the predominant antigen was the pandemic influenza virus АH1N1pdm09. Determination of the concentration of serum interleukins IL-1β, IL-4, IL-8, IL-10, ТNF-α, IFN-γ was performed in the 1st and 3rd day of hospitalization cytokines by the solid-phase immune-enzyme assay. Analysis of the results performed using statistical package SPSS 17.0 EN for Windows. Results: The flu caused the aggravation associated bronchopulmonary pathology in 2/3 of children, as MV patients, and patients with BA (65,4%-66,7%, respectively). With an increase of the ratio of IL-4 / IFN-γ and IL-10/IFN-γ, at least 5-6 times, influenza can be considered a trigger of exacerbation of chronic bronchopulmonary pathologies that require amplification of the therapy of bronchial asthma and of сystic fibrosis. The growth of prognostic coefficients in 2-3 times allows using for treatment of influenza in these patients only antiviral agents. Conclusion: The study has shown a method for predicting exacerbation of bronchial asthma and cystic fibrosis in children at an early stage of influenza by calculating the ratio of IL-4/IFN-γ and IL-10/IFN-γ in children aged from 1 year to 12 years.https://journal.niidi.ru/jofin/article/view/374детиинтерлейкининтерферонмуковисцидозбронхиальная астмагрипп |
| spellingShingle | O. I. Afanaseva E. G. Golovachyova V. S. Afanaseva V. F. Suhoveckaja E. A. Nikitina E. G. Koroleva А. V. Orlov L. B. Vayner L. A. Zhelenina Prediction of exacerbation chronic bronchopulmonary diseases in children with influenza Журнал инфектологии дети интерлейкин интерферон муковисцидоз бронхиальная астма грипп |
| title | Prediction of exacerbation chronic bronchopulmonary diseases in children with influenza |
| title_full | Prediction of exacerbation chronic bronchopulmonary diseases in children with influenza |
| title_fullStr | Prediction of exacerbation chronic bronchopulmonary diseases in children with influenza |
| title_full_unstemmed | Prediction of exacerbation chronic bronchopulmonary diseases in children with influenza |
| title_short | Prediction of exacerbation chronic bronchopulmonary diseases in children with influenza |
| title_sort | prediction of exacerbation chronic bronchopulmonary diseases in children with influenza |
| topic | дети интерлейкин интерферон муковисцидоз бронхиальная астма грипп |
| url | https://journal.niidi.ru/jofin/article/view/374 |
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