Multiresistant-MRSA tricuspid valve infective endocarditis with ancient osteomyelitis locus
<p>Abstract</p> <p>Background</p> <p>Methicillin-resistant <it>S. aureus </it>(MRSA) with low susceptibility to glycopeptides is uncommon.</p> <p>Case presentation</p> <p>The case of a 50-year-old non-drug addict patient presenting wi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2006-07-01
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| Series: | BMC Infectious Diseases |
| Online Access: | http://www.biomedcentral.com/1471-2334/6/124 |
| _version_ | 1818445196150439936 |
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| author | Gambarati Gianpaolo Mestres Carlos A Colli Andrea Chesi Giuseppe Boni Fabrizio Gherli Tiziano |
| author_facet | Gambarati Gianpaolo Mestres Carlos A Colli Andrea Chesi Giuseppe Boni Fabrizio Gherli Tiziano |
| author_sort | Gambarati Gianpaolo |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Methicillin-resistant <it>S. aureus </it>(MRSA) with low susceptibility to glycopeptides is uncommon.</p> <p>Case presentation</p> <p>The case of a 50-year-old non-drug addict patient presenting with tricuspid valve infective endocarditis (IE) by MRSA resistant to vancomycin and linezolid is presented. There was response only to quinupristin/dalfopristin. He had a motorcycling accident four years before undergoing right above-the-knee amputation and orthopaedic fixation of the left limb. There were multiple episodes of left MRSA-osteomyelitis controlled after surgery and vancomycin therapy. MRSA isolated from the blood at the time of IE presented with the same profile than the isolated four years earlier. Sequential treatment with teicoplanin-cotrimoxazole and Linezolid associated to vancomycin – rifampicin – cotrimoxazole had no improvement. Infection was controlled after 28 days of therapy with quinupristin/dalfopristin.</p> <p>Conclusion</p> <p>The literature presents only a few cases of MRSA IE not susceptible to glycopeptides in not drug addicted patients. This case shows the comparison of a highly-resistant MRSA after previous <it>S. aureus </it>osteomyelitis treated with glycopeptides. This is the first description of successful treatment of resistant-MRSA IE of the tricuspid valve complicated by multiple pulmonary septic infarction with quinupristin/dalfopristin</p> |
| first_indexed | 2024-12-14T19:27:59Z |
| format | Article |
| id | doaj.art-1597de78379b4fc0b731393077ac3714 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-14T19:27:59Z |
| publishDate | 2006-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-1597de78379b4fc0b731393077ac37142022-12-21T22:50:08ZengBMCBMC Infectious Diseases1471-23342006-07-016112410.1186/1471-2334-6-124Multiresistant-MRSA tricuspid valve infective endocarditis with ancient osteomyelitis locusGambarati GianpaoloMestres Carlos AColli AndreaChesi GiuseppeBoni FabrizioGherli Tiziano<p>Abstract</p> <p>Background</p> <p>Methicillin-resistant <it>S. aureus </it>(MRSA) with low susceptibility to glycopeptides is uncommon.</p> <p>Case presentation</p> <p>The case of a 50-year-old non-drug addict patient presenting with tricuspid valve infective endocarditis (IE) by MRSA resistant to vancomycin and linezolid is presented. There was response only to quinupristin/dalfopristin. He had a motorcycling accident four years before undergoing right above-the-knee amputation and orthopaedic fixation of the left limb. There were multiple episodes of left MRSA-osteomyelitis controlled after surgery and vancomycin therapy. MRSA isolated from the blood at the time of IE presented with the same profile than the isolated four years earlier. Sequential treatment with teicoplanin-cotrimoxazole and Linezolid associated to vancomycin – rifampicin – cotrimoxazole had no improvement. Infection was controlled after 28 days of therapy with quinupristin/dalfopristin.</p> <p>Conclusion</p> <p>The literature presents only a few cases of MRSA IE not susceptible to glycopeptides in not drug addicted patients. This case shows the comparison of a highly-resistant MRSA after previous <it>S. aureus </it>osteomyelitis treated with glycopeptides. This is the first description of successful treatment of resistant-MRSA IE of the tricuspid valve complicated by multiple pulmonary septic infarction with quinupristin/dalfopristin</p>http://www.biomedcentral.com/1471-2334/6/124 |
| spellingShingle | Gambarati Gianpaolo Mestres Carlos A Colli Andrea Chesi Giuseppe Boni Fabrizio Gherli Tiziano Multiresistant-MRSA tricuspid valve infective endocarditis with ancient osteomyelitis locus BMC Infectious Diseases |
| title | Multiresistant-MRSA tricuspid valve infective endocarditis with ancient osteomyelitis locus |
| title_full | Multiresistant-MRSA tricuspid valve infective endocarditis with ancient osteomyelitis locus |
| title_fullStr | Multiresistant-MRSA tricuspid valve infective endocarditis with ancient osteomyelitis locus |
| title_full_unstemmed | Multiresistant-MRSA tricuspid valve infective endocarditis with ancient osteomyelitis locus |
| title_short | Multiresistant-MRSA tricuspid valve infective endocarditis with ancient osteomyelitis locus |
| title_sort | multiresistant mrsa tricuspid valve infective endocarditis with ancient osteomyelitis locus |
| url | http://www.biomedcentral.com/1471-2334/6/124 |
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