Patient-centric design for peptide delivery: Trends in routes of administration and advancement in drug delivery technologies
Utilizing peptides as therapeutic agents is considered an attractive approach for the treatment of various diseases due to their high binding and selectivity to novel drug targets. However, the physicochemical properties of peptides make them challenging to administer exogenously, which places a hig...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-03-01
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| Series: | Medicine in Drug Discovery |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S259009862030066X |
| _version_ | 1818871221744304128 |
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| author | Ahil N. Ganesh Carolyn Heusser Sudhakar Garad Manuel Vicente Sánchez-Félix |
| author_facet | Ahil N. Ganesh Carolyn Heusser Sudhakar Garad Manuel Vicente Sánchez-Félix |
| author_sort | Ahil N. Ganesh |
| collection | DOAJ |
| description | Utilizing peptides as therapeutic agents is considered an attractive approach for the treatment of various diseases due to their high binding and selectivity to novel drug targets. However, the physicochemical properties of peptides make them challenging to administer exogenously, which places a high burden on drug delivery technology selection to successfully achieve the desired response. Various peptide drug delivery systems have been used in clinical and marketed products to overcome the problems associated with exogenous administration of peptide therapeutics. This review details the trends observed pertaining to the delivery of peptides such as changes in the routes of administration, advancements in formulation platforms, patient-centric product design, and various other aspects of peptide delivery. |
| first_indexed | 2024-12-19T12:19:29Z |
| format | Article |
| id | doaj.art-159be20c02e14145b38fb3a61c6f26ce |
| institution | Directory Open Access Journal |
| issn | 2590-0986 |
| language | English |
| last_indexed | 2024-12-19T12:19:29Z |
| publishDate | 2021-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Medicine in Drug Discovery |
| spelling | doaj.art-159be20c02e14145b38fb3a61c6f26ce2022-12-21T20:21:51ZengElsevierMedicine in Drug Discovery2590-09862021-03-019100079Patient-centric design for peptide delivery: Trends in routes of administration and advancement in drug delivery technologiesAhil N. Ganesh0Carolyn Heusser1Sudhakar Garad2Manuel Vicente Sánchez-Félix3Novartis Institutes for BioMedical Research, 700 Main Street, Cambridge, MA 02139, USANovartis Institutes for BioMedical Research, 700 Main Street, Cambridge, MA 02139, USANovartis Institutes for BioMedical Research, 700 Main Street, Cambridge, MA 02139, USACorresponding author.; Novartis Institutes for BioMedical Research, 700 Main Street, Cambridge, MA 02139, USAUtilizing peptides as therapeutic agents is considered an attractive approach for the treatment of various diseases due to their high binding and selectivity to novel drug targets. However, the physicochemical properties of peptides make them challenging to administer exogenously, which places a high burden on drug delivery technology selection to successfully achieve the desired response. Various peptide drug delivery systems have been used in clinical and marketed products to overcome the problems associated with exogenous administration of peptide therapeutics. This review details the trends observed pertaining to the delivery of peptides such as changes in the routes of administration, advancements in formulation platforms, patient-centric product design, and various other aspects of peptide delivery.http://www.sciencedirect.com/science/article/pii/S259009862030066XPeptidesDrug deliveryOralParenteralExtended releasePatient-centricity |
| spellingShingle | Ahil N. Ganesh Carolyn Heusser Sudhakar Garad Manuel Vicente Sánchez-Félix Patient-centric design for peptide delivery: Trends in routes of administration and advancement in drug delivery technologies Medicine in Drug Discovery Peptides Drug delivery Oral Parenteral Extended release Patient-centricity |
| title | Patient-centric design for peptide delivery: Trends in routes of administration and advancement in drug delivery technologies |
| title_full | Patient-centric design for peptide delivery: Trends in routes of administration and advancement in drug delivery technologies |
| title_fullStr | Patient-centric design for peptide delivery: Trends in routes of administration and advancement in drug delivery technologies |
| title_full_unstemmed | Patient-centric design for peptide delivery: Trends in routes of administration and advancement in drug delivery technologies |
| title_short | Patient-centric design for peptide delivery: Trends in routes of administration and advancement in drug delivery technologies |
| title_sort | patient centric design for peptide delivery trends in routes of administration and advancement in drug delivery technologies |
| topic | Peptides Drug delivery Oral Parenteral Extended release Patient-centricity |
| url | http://www.sciencedirect.com/science/article/pii/S259009862030066X |
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