Myofibroblastic CAF Density, Not Activated Stroma Index, Indicates Prognosis after Neoadjuvant Therapy of Pancreatic Carcinoma

Myofibroblastic CAF Density, Not Activated Stroma Index, Indicates Prognosis after Neoadjuvant Therapy of Pancreatic Carcinoma

Neoadjuvant therapy (NT) for advanced PDAC is an emerging concept, affecting both stroma and tumor. The Activated Stroma Index (ASI; ratio of activated cancer-associated fibroblasts (CAF) to collagen deposition) is a prognostic marker in upfront resected pancreatic adenocarcinoma (PDAC). We assessed...

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Bibliographic Details
Main Authors: Ulrike Heger, Anna Martens, Lisa Schillings, Britta Walter, Domenic Hartmann, Ulf Hinz, Thomas Pausch, Nathalia Giese, Christoph W. Michalski, Thilo Hackert
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cancers
Subjects:
pancreatic cancer
FOLFIRINOX
paclitaxel
neoadjuvant therapy
tumor stroma
CAF
Online Access:https://www.mdpi.com/2072-6694/14/16/3881

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